Results 81 to 90 of about 1,033,419 (194)

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +2 more sources

Dietary Serine Supplementation Improves Growth Performance, Intramuscular Fat Content, and Composition of Gut Microbes and Metabolites in Growing–Finishing Pigs

Agriculture
Serine is widely involved in antioxidant synthesis, immune response, and fat metabolism. However, it remains unclear whether dietary serine supplementation affects fat deposition in the skeletal muscles of pigs.
Yiting Guo, Fang He, Zhiying Deng, Jie Yin, Guiping Guan, Zhengjun Xie, Xihong Zhou   +6 more
doaj   +1 more source

Personal model‐assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD

Molecular Systems Biology, 2017
To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS).
Adil Mardinoglu, Elias Bjornson, Cheng Zhang, Martina Klevstig, Sanni Söderlund, Marcus Ståhlman, Martin Adiels, Antti Hakkarainen, Nina Lundbom, Murat Kilicarslan, Björn M Hallström, Jesper Lundbom, Bruno Vergès, Peter Hugh R Barrett, Gerald F Watts, Mireille J Serlie, Jens Nielsen, Mathias Uhlén, Ulf Smith, Hanns‐Ulrich Marschall, Marja‐Riitta Taskinen, Jan Boren   +21 more
doaj   +1 more source

Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats

Behavioral Sciences, 2018
The purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline.
Maria Elena González-Fraguela, Lisette Blanco-Lezcano, Caridad Ivette Fernandez-Verdecia, Teresa Serrano Sanchez, Maria de los A. Robinson Agramonte, Lidia Leonor Cardellá Rosales   +5 more
doaj   +1 more source

Supplementation with serine-enriched non-essential amino acids from minimum essential medium promotes blastocyst development of in vitro-fertilized bovine embryos

The Journal of Reproduction and Development
To produce an embryo, a high conception rate must be complied along with four evaluation criteria based on the timing of early cleavage and proper embryo morphology (hereafter, these blastocysts will be referred to as “four-criteria-compliant blastocysts”
Nobuhiko ITAMI, Yuji HIRAO
doaj   +1 more source

Serine Is an Essential Metabolite for Effector T Cell Expansion [PDF]

, 2017
H. Eric, Glenn R. Bantug, Takla Griss, Stephanie A. Condotta, Radia Marie Johnson, Bożena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L. Balmer, Mark Verway, Thomas C. Raissi, Harmony Tsui, Giselle M. Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M. Krawczyk, Adam Friedman, Mark Manfredi, Martin J. Richer, Christoph Hess, Russell G. Jones   +21 more
openalex   +1 more source

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

eLife, 2019
In eukaryotes, ribosome profiling provides insight into the mechanism of protein synthesis at the codon level. In bacteria, however, the method has been more problematic and no consensus has emerged for how to best prepare profiling samples.
Fuad Mohammad, Rachel Green, Allen R Buskirk   +2 more
doaj   +1 more source

Serine‐227 in the N‐terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma [PDF]

, 2020
Yayoi Matsumura‐Kimoto, Taku Tsukamoto, Yuji Shimura, Yoshiaki Chinen, Kazuna Tanba, Saeko Kuwahara‐Ota, Yuto Fujibayashi, Daichi Nishiyama, Reiko Isa, Junko Yamaguchi, Yuka Kawaji‐Kanayama, Tsutomu Kobayashi, Shigeo Horiike, Masafumi Taniwaki, Junya Kuroda   +14 more
openalex   +1 more source

Site‐directed mutagenesis of Serine‐72 reveals the location of the fructose 6‐phosphate regulatory site of the Agrobacterium tumefaciensADP‐glucose pyrophosphorylase [PDF]

, 2022
Mashael A. Alghamdi, Rania A. Hussien, Yuanzhang Zheng, Hiral Patel, Matías D. Asención Diez, Alberto Á. Iglesias, Dali Liu, Miguel A. Ballícora   +7 more
openalex   +1 more source