Results 241 to 250 of about 245,013 (288)
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Metabolism of the neuromodulator d-serine
Cellular and Molecular Life Sciences, 2010Over the past years, accumulating evidence has indicated that D-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-D-aspartate receptors in various brain areas. D-Serine is synthesized in glial cells and neurons by the pyridoxal-5' phosphate-dependent enzyme serine racemase, and it is released upon ...
POLLEGIONI, LOREDANO, SACCHI, SILVIA
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Serine and glycine metabolism in schizophrenic patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19921. The brain glycine is almost exclusively derived from serine via serine-hydroxymethyltransferase. 17 males schizophrenic inpatients and 10 males healthy volunteers were submitted to the serine tolerance test. 2. Plasma serine and glycine concentration were evaluated before and after 1, 2, 3, 4 hours of an oral load with L-serine to test the ...
A, Lucca, S, Cortinovis, V, Lucini
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Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases
2022Sphingolipids (SL) are a class of chemically diverse lipids that have important structural and physiological functions in eukaryotic cells. SL entail a long chain base (LCB) as the common structural element, which is typically formed by the condensation of L-serine and long chain acyl-CoA.
Lone, Museer A +2 more
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Neuroleptic effects on serine and glycine metabolism
Biological Psychiatry, 1993The concentrations of serine and glycine and the activity of serine hydroxymethyltransferase (SHMT) are abnormal in plasma and brains of schizophrenics. To further elucidate the possible role of neuroleptics on the metabolism of serine and glycine and the activity of SHMT, we studied the plasma of controls and schizophrenics on and off medications, the
S, Baruah, R, Waziri, A, Sherman
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Serine and one-carbon metabolism in cancer
Nature Reviews Cancer, 2016The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for ...
Ming Yang, Karen H. Vousden
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Regulatory phenomena in mammalian serine metabolism
Advances in Enzyme Regulation, 1967Abstract The biosynthesis of serine in mammalian liver may proceed by two parallel pathways. Serine in physiological concentrations inhibits P-serine phosphatase, the last reaction in the “phosphorylated pathway”. No amino acid inhibitors of the alternative pathway have been identified.
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Serine metabolism in rat embryos undergoing organogenesis
Development, 1985ABSTRACT Rat embryos (9·5 days gestation) were cultured for 48 h in heat-inactivated homologous serum containing [3-14C] serine. Analysis of the distribution of the radioactive label in the conceptus demonstrated that almost one half of the incorporated serine was cleaved to provide one-carbon units for the synthesis of purine and ...
P B, Rowe, A, Kalaizis
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Serine in plants: biosynthesis, metabolism, and functions
Trends in Plant Science, 2014Serine (Ser) has a fundamental role in metabolism and signaling in living organisms. In plants, the existence of different pathways of Ser biosynthesis has complicated our understanding of this amino acid homeostasis. The photorespiratory glycolate pathway has been considered to be of major importance, whereas the nonphotorespiratory phosphorylated ...
Roc, Ros +2 more
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Anaerobic Glucose and Serine Metabolism in Staphylococcus epidermidis
Microbiology, 1980Anaerobically grown Staphylococcus epidermidis fermented glucose with the production of lactate and trace amounts of acetate, formate and CO2. Isotopic and inhibitor studies, assays for key enzymes of different metabolic pathways, and fermentation balances, all indicated that glucose was metabolized principally via glycolysis and to a very limited ...
R, Sivakanesan, E A, Dawes
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Glyoxalase 2 Coordinates de Novo Serine Metabolism
ChemBioChemAbstractPhosphoglycerate dehydrogenase (PHGDH) is the first enzyme in de novo Ser biosynthesis. Numerous metabolic pathways rely on Ser as a precursor, most notably one‐carbon metabolism, glutathione biosynthesis, and de novo nucleotide biosynthesis.
Marissa N. Trujillo +10 more
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