Results 221 to 230 of about 1,285,254 (263)
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function [PDF]
Cell Metabolism, 2020 Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses.
Tak W Mak, Dirk Brenner, Karsten Hiller
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Serine metabolism in macrophage polarization
Inflammation Research, 2023Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of serine for their activation and functionalization, necessitating our insight into how serine availability and utilization impact macrophage activation and inflammatory responses.This article summarizes the reports published ...
Xinqiong, Huang +3 more
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Serine and one-carbon metabolism in cancer
Nature Reviews Cancer, 2016The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for ...
Karen Vousden
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Serine metabolism and psychosis
Psychiatry Research, 1984Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
R, Waziri +3 more
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Serine metabolism in Lactobacillus plantarum
International Journal of Food Microbiology, 2003This study investigated the metabolism of (L-) serine by Lactobacillus plantarum B3089 isolated from cheese. Serine was deaminated by growing cells to ammonia with the corresponding formation of acetate and formate. Serine was also deaminated by non-growing cells to ammonia but with the formation of acetate only (no production of formate ...
S-Q, Liu +3 more
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Metabolic control analysis of mammalian serine metabolism
Advances in Enzyme Regulation, 1990(1) Mammalian serine metabolism is discussed in relation to its synthesis and utilization in proliferating cells, particularly during the nonmalignant proliferation of lymphocytes. (2) An analysis of the control of serine biosynthesis de novo under conditions of high pathway flux has been carried out using metabolic control theory.
K, Snell, D A, Fell
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Serine and glycine metabolism in schizophrenic patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19921. The brain glycine is almost exclusively derived from serine via serine-hydroxymethyltransferase. 17 males schizophrenic inpatients and 10 males healthy volunteers were submitted to the serine tolerance test. 2. Plasma serine and glycine concentration were evaluated before and after 1, 2, 3, 4 hours of an oral load with L-serine to test the ...
A, Lucca, S, Cortinovis, V, Lucini
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Serine Metabolism After Portacaval Shunt
Archives of Surgery, 1970Although portacaval shunt effectively controls hemorrhage from esophageal varices by control of portal hypertension, liver function does not improve and often deteriorates after diversion of portal blood from the liver. Hepatic failure is the most common cause of the excessively high mortality following portacaval shunt. The etiology of hepatic failure
F A, Reichle +5 more
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Neuroleptic effects on serine and glycine metabolism
Biological Psychiatry, 1993The concentrations of serine and glycine and the activity of serine hydroxymethyltransferase (SHMT) are abnormal in plasma and brains of schizophrenics. To further elucidate the possible role of neuroleptics on the metabolism of serine and glycine and the activity of SHMT, we studied the plasma of controls and schizophrenics on and off medications, the
S, Baruah, R, Waziri, A, Sherman
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The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism [PDF]
Nucleic Acids Research, 2019 Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities.
Gian Gaetano Tartaglia +2 more
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