Results 31 to 40 of about 245,013 (288)

Pharmacokinetics of oral l-serine supplementation in a single patient

Molecular Genetics and Metabolism Reports, 2020
Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in ...
Danny E. Miller, Carlos R. Ferreira, Anna I. Scott, Irene J. Chang   +3 more
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
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Multi-omics Analysis of the Role of PHGDH in Colon Cancer

Technology in Cancer Research & Treatment, 2023
Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc, Lin Chen MSc, KaiLing Pan MSc, XiaoYa Zhao MSc, WenXia Xu PhD, JinLin Du MD, Chungen Xing PhD   +6 more
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Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

Cell Reports, 2018
Summary: Cell proliferation can be dependent on the non-essential amino acid serine, and dietary restriction of serine inhibits tumor growth, but the underlying mechanisms remain incompletely understood.
Xia Gao, Katie Lee, Michael A. Reid, Sydney M. Sanderson, Chuping Qiu, Siqi Li, Juan Liu, Jason W. Locasale   +7 more
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Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer

Discover Oncology, 2021
Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups.
Carlo Ganini, Ivano Amelio, Riccardo Bertolo, Eleonora Candi, Angela Cappello, Chiara Cipriani, Alessandro Mauriello, Carla Marani, Gerry Melino, Manuela Montanaro, Maria Emanuela Natale, Giuseppe Tisone, Yufang Shi, Ying Wang, Pierluigi Bove   +14 more
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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

Bone Research, 2022
The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the ...
Steve Stegen, Shauni Loopmans, Ingrid Stockmans, Karen Moermans, Peter Carmeliet, Geert Carmeliet   +5 more
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The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics Approach

Frontiers in Genetics, 2021
The use of differentiating human induced pluripotent stem cells (hiPSCs) in mini-tissue organoids provides an invaluable resource for regenerative medicine applications, particularly in the field of disease modeling.
Qizheng Wang, Yucui Xiong, Yucui Xiong, Sheng Zhang, Sheng Zhang, Yufei Sui, Cunlai Yu, Peng Liu, Heying Li, Wenjing Guo, Yubo Gao, Aneta Przepiorski, Alan J. Davidson, Meijin Guo, Xiao Zhang, Xiao Zhang   +15 more
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Lysine, Lysine-Rich, Serine, and Serine-Rich Proteins: Link Between Metabolism, Development, and Abiotic Stress Tolerance and the Role of ncRNAs in Their Regulation

Frontiers in Plant Science, 2020
Lysine (Lys) is indispensable nutritionally, and its levels in plants are modulated by both transcriptional and post-transcriptional control during plant ontogeny.
P. B. Kavi Kishor, Renuka Suravajhala, Guddimalli Rajasheker, Nagaraju Marka, Kondle Kavya Shridhar, Divya Dhulala, Korubothula Prakash Scinthia, Kummari Divya, Madhavi Doma, Sujatha Edupuganti, Prashanth Suravajhala, Rathnagiri Polavarapu   +11 more
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Serine Supports IL-1β Production in Macrophages Through mTOR Signaling

Frontiers in Immunology, 2020
Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism.
Siyuan Chen, Yaoyao Xia, Fang He, Jian Fu, Zhongquan Xin, Baichuan Deng, Liuqin He, Xihong Zhou, Wenkai Ren   +8 more
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Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

Computational and Structural Biotechnology Journal, 2021
Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic isozyme, and SHMT2 encoding the ...
Michele Monti, Giulia Guiducci, Alessio Paone, Serena Rinaldo, Giorgio Giardina, Francesca Romana Liberati, Francesca Cutruzzolá, Gian Gaetano Tartaglia   +7 more
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