Results 151 to 160 of about 422,331 (334)

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung [PDF]

, 2015
Matthew S. Twigg, Simon Brockbank, Philip Lowry, Sean Fitzgerald, Clifford C. Taggart, Sinéad Weldon   +5 more
openalex   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors.

, 1987
Paul C. Billings, Josephine A. Carew, Christine E. Keller-McGandy, Alfred L. Goldberg, Ann R. Kennedy   +4 more
openalex   +2 more sources

Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations [PDF]

, 2019
Anna Zawilak‐Pawlik, Urszula Zarzecka, Dorota Żyła-Uklejewicz, Jakub Lach, Dominik Strapagiel, Nicole Tegtmeyer, Manja Böhm, Steffen Backert, Joanna Skórko‐Glonek   +8 more
openalex   +1 more source

Supplementary Figure Legends from Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells

, 2023
Haley L. Peters, S. C. Tripathi, Céline Kerros, Hiroyuki Katayama, Haven R. Garber, Lisa S. St. John, Lorenzo Federico, Ismail M. Meraz, Jack A. Roth, Boris Sepesi, Mourad Majidi, Kathryn Ruisaard, Karen Clise-Dwyer, Jason Roszik, Don L. Gibbons, John V. Heymach, Stephen G. Swisher, Chantale Bernatchez, Gheath Alatrash, Samir Hanash, Jeffrey J. Molldrem   +20 more
openalex   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Serine Protease Inhibitors [PDF]

, 2006
  +5 more sources

Sodium‐site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study [PDF]

, 2019
Kanagasabai Vadivel, Herman Schreuder, A. Liesum, Amy E. Schmidt, Gunaseelan Goldsmith, S Paul Bajaj   +5 more
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source