Results 191 to 200 of about 422,331 (334)

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Phosphorylation of EF-P aggravates Streptococcus suis-induced blood-brain barrier damage by enhancing serine protease production. [PDF]

Vet Res
Yin H, Tian Y, Zhou Z, Lang S, Li Y, Peng L, Li J, Fang R.   +7 more
europepmc   +1 more source

Serine Protease Hepsin [PDF]

, 2020
openaire   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Procoagulant Effects of <i>Bothrops diporus</i> Venom: Kinetic Modeling and Role of Serine Protease Activity. [PDF]

Int J Mol Sci
Lopez GL, Nielsen SA, Nielsen VG, Fusco LS.   +3 more
europepmc   +1 more source

Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies [PDF]

Richard Kontoh-Twumasi, Stepan Budkin, Neel Edupuganti, Ayushi Vashishtha, Shruti Sharma   +4 more
openalex   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection. [PDF]

PLoS Pathog
Brokaw A, Wallen G, Orvis A, Kwon HJ, Seepersaud R, Nguyen S, Sharma K, Coleman M, Quach P, Twentyman J, Vornhagen J, Jones LA, Lin C, Gafken PR, Rajagopal L.   +14 more
europepmc   +1 more source

N-terminal Processing Is Essential for Release of Epithin, a Mouse Type II Membrane Serine Protease [PDF]

, 2001
Eun‐Gyung Cho, Moon Gyo Kim, Chungho Kim, Seung-Ryul Kim, Ihn Sik Seong, Chin-Ha Chung, Ronald H. Schwartz, Dongeun Park   +7 more
openalex   +1 more source