Results 191 to 200 of about 358,313 (362)

Autosomal recessive hyper‐IgE syndrome due to DOCK8 deficiency: An adjunctive role for omalizumab

open access: yesJournal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 222-226, December 2022., 2022
We report a rare case of AR‐HIES with DOCK8 deficiency in a young male that was successfully treated by infection management, skincare, diet elimination, and omalizumab. Abstract Autosomal recessive hyper‐IgE syndrome (AR‐HIES) is a rare primary immunodeficiency disorder characterized by high serum IgE levels, recurrent viral skin infections, severe ...
Kim Han Nguyen   +8 more
wiley   +1 more source

High‐Fidelity In Vitro Packaging of Diverse Synthetic Cargo into Encapsulin Protein Cages

open access: yesAngewandte Chemie, EarlyView.
Pack n’ Play. A novel in vitro assembly system for encapsulin protein cages has been developed. Using a bulky fusion partner to prevent shell assembly in cellulo, high‐fidelity assembly is triggered in vitro by proteolytic cleavage yielding robust particles with superior thermostability.
Taylor N. Szyszka   +8 more
wiley   +2 more sources

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

open access: yesAggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong   +11 more
wiley   +1 more source

Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins

open access: yesAngewandte Chemie, EarlyView.
The sequence (PQYQP), derived from the SRC protein, was combined with the self‐assembly motif (Nap‐FF) to produce intrinsically disordered peptide (IDP) assemblies that form cell‐compatible hydrogels via enzyme‐instructed self‐assembly (EISA). Abstract Intrinsically disordered regions (IDRs) are ubiquitous in proteins, orchestrating complex cellular ...
Yuchen Qiao   +7 more
wiley   +2 more sources

π‐PhenoDrug: A Comprehensive Deep Learning‐Based Pipeline for Phenotypic Drug Screening in High‐Content Analysis

open access: yesAdvanced Intelligent Systems, EarlyView.
This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li   +7 more
wiley   +1 more source

Computer-generated models of blood coagulation factor Xa, factor IXa, and thrombin based upon structural homology with other serine proteases.

open access: hybrid, 1982
Bruce Furie   +5 more
openalex   +1 more source

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