Results 211 to 220 of about 425,250 (334)

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Procoagulant Effects of <i>Bothrops diporus</i> Venom: Kinetic Modeling and Role of Serine Protease Activity. [PDF]

Int J Mol Sci
Lopez GL, Nielsen SA, Nielsen VG, Fusco LS.   +3 more
europepmc   +1 more source

The extracellular serine protease from Staphylococcus epidermidis elicits a type 2-biased immune response in atopic dermatitis patients [PDF]

Goran Abdurrahman, Rebecca Pospich, Leif Steil, Manuela Gesell Salazar, Juan José Izquierdo González, Nicole Normann, Daniel M. Mrochen, Christian Scharf, Uwe Völker, Thomas Werfel, Barbara M. Bröker, Lennart M. Roesner, Lídia Gómez‐Gascón   +12 more
openalex   +1 more source

Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum [PDF]

, 1997
Itaru Terai, Kunihiko Kobayashi, Misao Matsushita, Teizo Fujita   +3 more
openalex   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection. [PDF]

PLoS Pathog
Brokaw A, Wallen G, Orvis A, Kwon HJ, Seepersaud R, Nguyen S, Sharma K, Coleman M, Quach P, Twentyman J, Vornhagen J, Jones LA, Lin C, Gafken PR, Rajagopal L.   +14 more
europepmc   +1 more source

An Emerging Role for Serine Protease Inhibitors in T Lymphocyte Immunity and Beyond [PDF]

, 2012
Philip G. Ashton‐Rickardt
openalex   +1 more source

Systematic functional analysis and potential application of a serine protease from cold-adapted Planococcus bacterium

, 2023
Weijun Leng, Xiaoyun Wu, Xianghui Qi, Hongying Liu, Li Yuan, Ruichang Gao   +5 more
openalex   +1 more source

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

<i>In Silico</i> Structural Analysis of the Grapevine Serine Protease VviSBT4.19 Involved in Defense against <i>P. viticola</i>. [PDF]

J Agric Food Chem
Rodrigues FEP, Ferreira SGF, Paiva-Silva C, Figueiredo A, Santos RB, Machuqueiro M.   +5 more
europepmc   +1 more source