Results 211 to 220 of about 372,460 (343)

How morphogen gradients form – of FGF signals, a secreted serine protease, and a feedback-regulated protease inhibitor [PDF]

The formation of morphogen gradients is of fundamental importance in biology. Fibroblast growth factors (FGFs) have key functions in embryonic development and the adult, yet little is known about how the distribution and strength of these signals is ...
ایلیو, دوبرومیر, سقا, محسن, مین, تان هویی, پرا, ادگار, گریزباخ, جولیا   +4 more
core   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

Aggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky, Olesya V. Stepanenko, Olga V. Stepanenko, Anna I. Sulatskaya   +3 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages. [PDF]

Parasit Vectors
de Almeida Machado P, Gomes PS, Coimbra ES, de Matos Guedes HL.   +3 more
europepmc   +1 more source

The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis.

, 1993
L. Appel, Mary Prout, Robin Abu-Shumays, Ann S. Hammonds, James C. Garbe, D Fristrom, James W. Fristrom   +6 more
openalex   +1 more source

Two Lineages of Mannose-Binding Lectin-Associated Serine Protease (MASP) in Vertebrates [PDF]

, 1998
Yuichi Endo, Minoru Takahashi, Miki Nakao, Hidetoshi Saiga, Hideharu Sekine, Misao Matsushita, Masaru Nonaka, Teizo Fujita   +7 more
openalex   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

Animal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv, Ming Liu, Feifei Qi, Mingya Liu, Fengdi Li, Ran Deng, Xujian Liang, Yanfeng Xu, Zhiqi Song, Yiwei Yan, Shuyue Li, Guocui Mou, Linlin Bao   +12 more
wiley   +1 more source

Investigation on the Substrate Specificity of Serine Protease Neuropsin by Molecular Dynamics Simulation and Marmoset Gene Atlas (MGA). [PDF]

ACS Omega
Lintuluoto M, Horioka Y, Fujiwara M, Abe M, Fukunishi Y, Tamura H, Lintuluoto JM.   +6 more
europepmc   +1 more source

Site-directed mutagenesis suggests close functional relationship between a human rhinovirus 3C cysteine protease and cellular trypsin-like serine proteases.

, 1990
Keat-Chye Cheah, Louis E.-C. Leong, Alan G. Porter   +2 more
openalex   +1 more source