Results 241 to 250 of about 422,331 (334)

Targeting the Liver Serine Protease TMPRSS6 Ameliorates Steatosis and Attenuates Fibrosis in Experimental MASLD. [PDF]

Liver Int
Pettinato M, Furiosi V, Carleo R, Bavuso Volpe L, Guo S, Mannella V, Musco G, Gilberti E, De Palma G, Federico G, Carlomagno F, Cherubini A, Pelusi S, Dano A, Nai A, Valenti L, Altamura S, Pagani A, Silvestri L.   +18 more
europepmc   +1 more source

Mannan-binding lectin (MBL) associated serine protease-3 (MASP-3) : complex formation in serum and plasma, conditions required for the conversion of the zymogen form into a two-chain serin protease, and a search for substrates using recombinant material produced by stable expression in eukaryotic cell lines

, 2004
Mads Ronald Dahl
openalex   +1 more source

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway [PDF]

, 2013
Márton Megyeri, Veronika Harmat, Balázs Major, Ádám Végh, Júlia Balczer, Dávid Héja, Katalin Szilágyi, Dániel Datz, Gábor Pál, Péter Závodszky, Péter Gál, József Dobó   +11 more
openalex   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

<i>Tequila</i>, the Serine Protease, Is Involved in Sleep-Dependent Memory Consolidation in <i>Drosophila</i>. [PDF]

eNeuro
Segu A, Sansaria S, Kannan NN.
europepmc   +1 more source

Neutrophil serine proteases as novel biomarkers for autoimmune diabetes

, 2014
Yu Wang
openalex   +1 more source

Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum [PDF]

, 1997
Itaru Terai, Kunihiko Kobayashi, Misao Matsushita, Teizo Fujita   +3 more
openalex   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway. [PDF]

PLoS Negl Trop Dis
Zheng WW, Zhang XZ, Cong PK, Zhang R, Long SR, Zhang X, Liu RD, Wang ZQ, Cui J.   +8 more
europepmc   +1 more source

Purification and biological characterization of a new serine protease with thrombin "like" activity the whole venom of Brothrops andianus (TLBan)

, 2012
Valeriano Zapana, José Antonio, 1985-
openalex   +1 more source