Results 241 to 250 of about 425,250 (334)

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations. [PDF]

J Biol Chem
Hagemeier B, Ripkens K, Schulze N, Bluemke A, Strzala M, Koci M, Kaschani F, Kaiser M, Erkelenz M, Schluecker S, Merdanovic M, Poepsel S, Hellerschmied D, Burston SG, Ehrmann M.   +14 more
europepmc   +1 more source

Molecular study on the effect of Tea Tree Oil and its polymer on gene expression of serine protease autotransporter genes of uropathogenic Escherichia coli

Salwa Ahmed Alkarady, Ghusoon A. Abdulhasan   +1 more
openalex   +1 more source

A novel form of human neuropsin, a brain‐related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain [PDF]

, 1999
Shinichi Mitsui, Nobuo Tsuruoka, Kyoko Yamashiro, Hiroshi Nakazato, Nozomi Yamaguchi   +4 more
openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Serine protease inhibitor dipetalogastin-like from Galleria mellonella is involved in insect immunity. [PDF]

Sci Rep
Kordaczuk J, Sułek M, Mak P, Pawlikowska-Pawlęga B, Wojda I.   +4 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Structural characterization and biophysical analysis of recombinant SpoIVB variants: insights into PDZ and serine protease domain interactions. [PDF]

Microbiol Spectr
Zhu J, Zhang X, Zhang X, Sun G, Xu P, Yuan C, Huang M, Jiang L.   +7 more
europepmc   +1 more source

Growth Hormone Rapidly Activates Rat Serine Protease Inhibitor 2.1 Gene Transcription and Induces a DNA-Binding Activity Distinct from Those of Stat1, -3, and -4

, 1995
Michael J. Thomas, Ann M. Gronowski, Susan A. Berry, Pearl L. Bergad, Peter Rotwein   +4 more
openalex   +2 more sources

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source