Results 61 to 70 of about 358,313 (362)

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

The role of Serine Proteases and Serine Protease Inhibitors in the migration of Gonadotropin-Releasing Hormone neurons [PDF]

BMC Developmental Biology, 2002
Background: Mechanisms regulating neuronal migration during development remain largely undefined. Extracellular matrix cues, target site released factors, and components of the migratory neurons themselves are likely all coordinated in time and space directing neurons to their appropriate locations.
Drapkin, Paola, Monard, Denis, Silverman, Ann-Judith   +2 more
openaire   +4 more sources

Overhydration Measured by Bioimpedance Spectroscopy and Urinary Serine Protease Activity Are Risk Factors for Progression of Chronic Kidney Disease

Kidney & Blood Pressure Research, 2020
Background: Overhydration (OH) is common in chronic kidney disease (CKD) and might be related to the excretion of urinary serine proteases. Progression of CKD is associated with proteinuria; however, the interrelations of urinary serine proteases, OH ...
Anja Schork, Bernhard N. Bohnert, Nils Heyne, Andreas L. Birkenfeld, Ferruh Artunc   +4 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
Abbott, Abbott, Abbott, Acharya, Adams, Adams, Aertgeerts, Aimes, Alcolado, Aoyama, Ariga, Artym, Bangert, Barrett, Bauvois, Bermpohl, Birney, Bissell, Brendan F. O'Connor, Brown, Busek, Chen, Chen, Chen, Chen, Cheng, Cheng, Christiansen, Collins, Corpet, De Wever, Del Rosso, Dolznig, Dvorak, Edosada, Edosada, Fassnacht, Fidler, Fink, Flentke, Fulop, Garcia-Horsman, Garin-Chesa, Gerner, Ghersi, Ghersi, Ghersi, Gilmore, Goldstein, Goldstein, Goodman, Gorrell, Guex, Hofheinz, Huang, Huber, Huber, Ibrahim, Iwasa, Jin, Kelly, Kelly, Kelly, Kelly, Kloft, Koyama, Lee, Lee, Lee, Lee, Lee, Levy, Levy, Levy, Loeffler, Mathew, Mersmann, Milner, Monsky, Mori, Mueller, Nicholas, Niedermeyer, Niedermeyer, Niedermeyer, Oertel, Okada, Okada, Ollis, Pamela O'Brien, Park, Pineiro-Sanchez, Ramirez-Montagut, Rennex, Rettig, Rettig, Rettig, Rettig, Rosenblum, Samel, Scanlan, Schechter, Scott, Scott, Sieweke, Skubitz, Stremenova, Sun, Tahtis, Tran, Wang, Wang, Welt, Welt, Wesley, Zhang   +115 more
core   +1 more source

Functions and evolution of FAM111 serine proteases

Frontiers in Molecular Biosciences, 2022
Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease involved in two seemingly distinct processes: DNA replication and antiviral defense. FAM111A localizes to nascent DNA and plays a role at the DNA replication fork.
Allison L. Welter, Allison L. Welter, Yuichi J. Machida   +2 more
openaire   +3 more sources

Effect of supplemental serine-protease from Bacillus licheniformis on growth performance and physiological change of broiler chickens

Journal of Applied Animal Research, 2020
An experimental study was conducted to examine the effects of adding serine-protease from Bacillus licheniformis on performance and physiological parameters of broiler chickens under Egyptian condition.
Ahmed A. Saleh, Mustafa M. Dawood, Nemat A. Badawi, Tarek A. Ebeid, Khairy A. Amber, Mahmoud M. Azzam   +5 more
doaj   +1 more source

Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros. [PDF]

PLoS ONE, 2010
Serine proteases are a major component of viper venoms and are thought to disrupt several distinct elements of the blood coagulation system of envenomed victims. A detailed understanding of the functions of these enzymes is important both for acquiring a
Sakthivel Vaiyapuri, Robert A Harrison, Andrew B Bicknell, Jonathan M Gibbins, Gail Hutchinson   +4 more
doaj   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Geissler, Claudia, Jochum, Marianne, Naegler, Dorit K., Nerlich, Andreas, Neth, Peter, Profanter, Birgit, Sommerhoff, Christian P.   +6 more
core   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

New Candidates for Furin Inhibition as Probable Treat for COVID-19: Docking Output [PDF]

arXiv, 2021
Furin is a serine protease that takes part in the processing and activation of the host cell pre-proteins. The enzyme also plays an important role in the activation of several viruses like the newly emerging SARS-CoV-2 virus that causes COVID-19 disease with a high rate of virulence and mortality.
arxiv