Results 91 to 100 of about 541,956 (367)
Advanced Biology, EarlyView.The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo +5 more
wiley +1 more source
F1000Research, 2018 Background: Cervical-vaginal fluid (CVF) hydrates the mucosa of the lower female reproductive tract and is known to contain numerous proteases. The low pH of CVF (4.5 or below in healthy women of reproductive age) is a uniquely human attribute and poses ...
Carla M.J. Muytjens +2 more
doaj +1 more source
TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer
Experimental and Molecular Medicine, 2023 Proteases are involved in almost all biological processes, implying their importance for both health and pathological conditions. Dysregulation of proteases is a key event in cancer.
Semi Kim
doaj +1 more source
Serine proteases and serine protease inhibitors in testicular physiology: the plasminogen activation system [PDF]
Reproduction, 2007 The testis is an organ in which a series of radical remodeling events occurs during development and in adult life. These events likely rely on a sophisticated network of proteases and complementary inhibitors, including the plasminogen activation system. This review summarizes our current knowledge on the testicular occurrence and expression pattern of
openaire +3 more sources
Advanced Functional Materials, EarlyView.Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao +8 more
wiley +1 more source
Virtual Screening of Transmembrane Serine Protease Inhibitors
Bio-Protocol, 2017 The human family of type II transmembrane serine proteases includes 17 members. The defining features of these proteases are an N-terminal transmembrane domain and a C-terminal serine protease of the chymotrypsin (S1) fold, separated from each other by a
Antti Poso +2 more
doaj +1 more source
Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]
, 1990 The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core
Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]
, 2019 Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi +10 more
wiley +1 more source
Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function
Toxins, 2010 Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities.
Nathalie Dautin
doaj +1 more source