Results 101 to 110 of about 541,956 (367)
Microbial carcinogenic toxins and dietary anti-cancer protectants [PDF]
, 2017 Several toxins are known which account for the ability of some bacteria to initiate or promote carcinogenesis. These ideas are summarised and evidence is discussed for more specific mechanisms involving chymotrypsin and the bacterial chymotryptic enzyme ...
Darlington, L. Gail, Stone, Trevor W.
core +2 more sources
Inhibition of Serine Proteases by Arylboronic Acids [PDF]
Proceedings of the National Academy of Sciences, 1971 Arylboronic acids were found to be strong competitive inhibitors of subtilisin and chymotrypsin. The binding constants are strongly pH dependent and give a Hammett-type plot with a slope of -0.885. The pH dependence, the Hammett plot, and nmr model-system studies indicate that inhibition is due to electron-pair donation by the active site histidine to ...
Manfred Philipp, Myron L. Bender
openaire +3 more sources
Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration
Advanced Healthcare Materials, EarlyView.GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim +7 more
wiley +1 more source
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD
BMC Pulmonary Medicine, 2020 Background The increasing trend of Chronic Obstructive Pulmonary Disease (COPD) in becoming the third leading cause of deaths by 2020 is of great concern, globally as well as in India.
Durga Mahor +10 more
doaj +1 more source
Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo. [PDF]
PLoS ONE, 2015 The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in ...
Andreas Glenthøj +3 more
doaj +1 more source
Engineering novel complement activity into a pulmonary surfactant protein [PDF]
, 2010 Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble +38 more
core +2 more sources
Membrane-anchored serine proteases in vertebrate cell and developmental biology.
Annual Review of Cell and Developmental Biology, 2011 Analysis of vertebrate genome sequences at the turn of the millennium revealed that a vastly larger repertoire of enzymes execute proteolytic cleavage reactions within the pericellular and extracellular environments than was anticipated from biochemical ...
R. Szabo, T. Bugge
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi +26 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2008 We report for the first time the expression of multiple protease activities in the first instar larva (L1) of the flesh fly Oxysarcodexia thornax (Walker).
Patrícia Cuervo +7 more
doaj +1 more source
Protean proteases: At the cutting edge of lung diseases [PDF]
, 2017 Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical ...
Borensztajn, Keren S. +11 more
core +3 more sources