Results 91 to 100 of about 287,026 (286)

Human bradykinin B2 receptor is activated by kallikrein and other serine proteases.

, 2000
Human bradykinin B2 receptor is activated by kallikrein and other serine ...
Claudie Michele. Hecquet (7976993)
core   +4 more sources

Serine protease activities in Oxysarcodexia thornax (Walker) (Diptera: Sarcophagidae) first instar larva

Memorias do Instituto Oswaldo Cruz, 2008
We report for the first time the expression of multiple protease activities in the first instar larva (L1) of the flesh fly Oxysarcodexia thornax (Walker).
Patrícia Cuervo, Camila Mesquita-Rodrigues, Claudia Masini d'Avila Levy, Constança Britto, Fabiano Araújo Pires, Rodrigo Gredilha, Carlos Roberto Alves, Jose Batista de Jesus   +7 more
doaj   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

A structural mechanism of flavonoids in inhibiting serine proteases

, 2017
The crystal structure of quercerin:uPA reveals that catechol serves as the functional group in inhibiting serine proteases.
Xu Wang, Longguang Jiang, Mingdong Huang, Guangpu Xue, Lihu Gong, Mingming Xu, Cai Yuan   +6 more
core   +1 more source

Tailored Cationic Visible‐Light‐Active Interfaces for Sustainable, Biodegradable Nanofibers With Dual‐Mode Antimicrobial Activity and Robust Electrostatic Particle Capture

Advanced Materials, EarlyView.
Surface co‐functionalization of biodegradable nanofibers with sodium copper chlorophyllin and quaternary ammonium compounds achieves synergistic antimicrobial activity through combined photodynamic and contact‐killing mechanisms. The cationic surface provides humidity‐resistant electrostatic particle capture while maintaining rapid enzymatic ...
Dong Uk Lee, Jae Hak Shin, Seung Yeon Lee, In Ho Kim, Jiho Choi, Joon Young Park, Sang Bok Kim, Jeong Sang Son, Sang Hun Kim, Jae Hee Jung, Dong Yun Choi   +10 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa

Veterinary Research, 2011
Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined.
Glorieux Sarah, Favoreel Herman W, Steukers Lennert, Vandekerckhove Annelies P, Nauwynck Hans J   +4 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Heterocyclic Inhibitors Of Serine Proteases

, 1992
This invention relates to a novel class of heterocyclic compounds useful for selectively inhibiting elastase, selectively inhibiting chymotrypsin-like enzymes, selectively inhibiting trypsin-like enzymes, or for generally inhibiting serine proteases of ...

core   +1 more source