Results 171 to 180 of about 95,273 (247)

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, EarlyView.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +2 more sources

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [PDF]

Autophagy
Yuan J, Ma J, Zhang F, Wang T, Jian X, Wang B, Li W, Zhang X, Cao Y, Yang H, Ma Y, Wang H.   +11 more
europepmc   +1 more source

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

, 2023
Corre M, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +2 more sources

New advances in understanding inhibition of myeloperoxidase and neutrophil serine proteases by two families of staphylococcal innate immune evasion proteins. [PDF]

Arch Biochem Biophys
Herdendorf TJ, Mishra N, Fatehi S, Gido CD, Prakash O, Geisbrecht BV.   +5 more
europepmc   +1 more source

Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases. [PDF]

Int J Mol Sci
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +2 more sources

Proteomics of Bacterial and Mouse Extracellular Vesicles Released in the Gastrointestinal Tracts of Nutrient-Stressed Animals Reveals an Interplay Between Microbial Serine Proteases and Mammalian Serine Protease Inhibitors. [PDF]

Int J Mol Sci
Stentz R, Jones E, Gul L, Latousakis D, Parker A, Brion A, Goldson AJ, Gotts K, Carding SR.   +8 more
europepmc   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Homology-based identification and structural analysis of Pangasius hypophthalmus Annexins and Serine proteases to search molecules for wound healing applications. [PDF]

Comput Struct Biotechnol J
Avila Rodríguez MI, Velez Rueda AJ, Hernández-Pérez J, Benavides J, Sanchez ML.   +4 more
europepmc   +1 more source