Results 191 to 200 of about 95,273 (247)

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Plasma levels of mannan-binding lectin-associated serine proteases are increased in type 1 diabetes patients with insulin resistance. [PDF]

Clin Exp Immunol
Kietsiriroje N, Scott GE, Ajjan RA, Brôz J, Schroeder V, Campbell MD.   +5 more
europepmc   +1 more source

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An Overview of Serine Proteases

Current Protocols in Protein Science, 2001
AbstractThis unit summarizes the families of serine proteases and their mechanism of catalysis. Methods for assays and determining substrate specificity are briefly described. The mode of action of commonly available inhibitors is also included.
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Hydrolysis of polyesters by serine proteases

Biotechnology Letters, 2005
The substrate specificity of alpha-chymotrypsin and other serine proteases, trypsin, elastase, proteinase K and subtilisin, towards hydrolysis of various polyesters was examined using poly(L-lactide) (PLA), poly(beta-hydroxybutyrate) (PHB), poly(ethylene succinate) (PES), poly(ethylene adipate) (PEA), poly(butylene succinate) (PBS), poly(butylene ...
Hyun-A, Lim, Takao, Raku, Yutaka, Tokiwa
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Inhibition of serine proteases by steroids

Biochemical Pharmacology, 1982
Proteolysis of 14C-labeled globin, as well as the hydrolysis of the specific substrate benzoyl tyrosine ethyl ester, by purified bovine chymotrypsin was found to be inhibited by several steroid hormones. The inhibition of chymotrypsin by the steroids was of a competitive nature, with Ki values of 9.9 x 10(-5) M for triamcinolone (9-fluoro-11 beta, 16 ...
M, Mayer, B, Neufeld, Z, Finci
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Genomic overview of serine proteases

Biochemical and Biophysical Research Communications, 2003
Serine proteases (SP) are peptidases with a uniquely activated serine residue in the substrate-binding pocket. They represent about 0.6% of all proteins in the human genome. SP are involved in many vital functions such as digestion, blood clotting, fibrinolysis, fertilization, and complement activation and are related to many diseases including cancer,
George M, Yousef, Ari D, Kopolovic, Marc B, Elliott, Eleftherios P, Diamandis   +3 more
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Strategies for the inhibition of serine proteases

Cellular and Molecular Life Sciences, 2001
Serine proteases have been shown to play a multifarious role in health and disease. As a result, there has been considerable interest in the design and development of synthetic inhibitors of these enzymes. In view of their diverse roles in biological processing events, one of the great challenges in such endeavours has been the need to produce ...
B, Walker, J F, Lynas
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Serine proteases and cardiac function

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
The serine proteases of the trypsin superfamily are versatile enzymes involved in a variety of biological processes. In the cardiovascular system, the importance of these enzymes in blood coagulation, platelet activation, fibrinolysis, and thrombosis has been well established.
Qingyu, Wu, Hai-Chien, Kuo, Gary Gang, Deng   +2 more
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The novel inhibitors of serine proteases

Amino Acids, 2009
Thirty optically active nonprotein alpha-amino acids and peptides based thereon have been screened for their ability to interact with bovine trypsin and proteinase K from Tritirachium album Limber, which belong to the group of serine proteases. Both structure-based drug design approach and determination of enzyme activity have been used to identify low
N, Hovhannisyan, Sh, Harutyunyan, A, Hovhannisyan, A, Hambardzumyan, M, Chitchyan, M, Melkumyan, G, Oganezova, N, Avetisyan   +7 more
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Serine proteases of the complement system

Biochemical Society Transactions, 2000
The complement system in blood plasma is a major mediator of innate immune defence. The function of complement is to recognize, then opsonize or lyse, particulate materials, including bacteria, yeasts and other microrganisms, host cell debris and altered host cells.
R B, Sim, A, Laich
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