Results 151 to 160 of about 183,910 (327)

Proteomic analysis of skin invasion by blood fluke larvae. [PDF]

, 2008
BackgroundDuring invasion of human skin by schistosome blood fluke larvae (cercariae), a multicellular organism breaches the epidermis, basement membrane, and dermal barriers of skin.
Braschi, Simon, Debnath, Moumita, Hansell, Elizabeth, Ingram, Jessica, Lim, KC, McKerrow, James H, Medzihradszky, Katalin F, Sajid, Mohammed   +7 more
core   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

The effect of subtilisin-like serine protease Bacillus pumilus and histidine acid 3-phytase Pantoea brenneri on growth performance, digestibility, immune organs, and expression of intestinal barrier genes in broiler chickens [PDF]

Daria Pudova, Danil Kovalenko, Marat Lutfullin, Guzel Lutfullina, Margarita Sharipova, Abd El-Hack, M Alagawany, M Arif, M Emam, M Saeed, M Arain, M, H Akyurek, M Ozduven, A Okur, H Azzaz, Abd El Tawab, A Khattab, M Szumacher-Strabel, M Cielak, A Murad, H, M Borda, T Zuber, W Siegert, A Camarinhasilva, D Feuerstein, M Rodehutscord, D Bulmakova, S Smolentsev, A Suleimanova, G Hadieva, M Lutfullin, A Mardanova, Y Cai, X Shen, C Ding, C Qi, K Li, X Li, Y Cheng, F Hsiao, C Wen, C Wu, A Dybus, Y Yu, T Chung, S Rutherfurd, D Thomas, P Moughan, A Cowieson, O Adeola, D Cupi, M Thorsen, S Elvig-Jrgensen, L Wulf-Andersen, J Berti-Sorbara, J Cowieson, A, De Sousa, J Albino, L Vaz, R Rodrigues, K, Dersjant Li, Y Awati, A Schulze, H Partridge, G, G Dobreva, R Waeber, W James, C Widmann, M Faure, C Mettraux, D Moennoz, J Godin, J Vuichoud, F Rochat, D Freitas, S Vieira, C Angel, A Favero, A Maiorka, U Gadde, S Oh, Y Lee, E Davis, N Zimmerman, T Rehberger, I Giannenas, E Bonos, V Anestis, G Filioussis, D Papanastasiou, T Bartzanas, M Johansson, M Phillipson, J Petersson, A Velcich   +99 more
openalex   +1 more source

Caldolysin, a highly active protease from an extremely Thermophilic Bacterium [PDF]

, 1982
Proteases comprise a significant proportion of those proteins which have been subject to detailed characterisation (amino acid sequence and high resolution crystallographic analysis).
Cowan, Don A., Daniel, Roy M., Morgan, Hugh W.   +2 more
core   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Serine Protease from Nereis virens Inhibits H1299 Lung Cancer Cell Proliferation via the PI3K/AKT/mTOR Pathway [PDF]

, 2019
Yanan Chen, Yunping Tang, Yanhua Tang, Zuisu Yang, Guofang Ding, Zuisu Yang, Guofang Ding   +6 more
openalex   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Advanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang, Lili Niu, Xiang Ding, Mengmeng Zhang, Zhensheng Xie, Tanxi Cai, Xiaojing Guo, Jianming Luo, Peng An, Xiangqian Guo, Fuquan Yang   +13 more
wiley   +1 more source

Decision letter: A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

, 2017

openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.

, 1991
Marisa E. McGrath, Wade Hines, Judy A. Sakanari, R.J. Fletterick, Charles S. Craik   +4 more
openalex   +1 more source