Results 161 to 170 of about 183,910 (327)

Studying the structural basis for selectivity in complexes of peptide inhibitors and serine proteases of the complement system [PDF]

, 2019
Zsolt Dürvanger, Eszter Boros, Rózsa Hegedüs, József Dobó, Andrea Kocsis, Krisztián Fodor, Péter Gál, Gábor Mező, Gábor Pál, Veronika Harmat, Dóra K. Menyhárd   +10 more
openalex   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Antifungal, Antimycobacterial, Protease and α‒Amylase Inhibitory Activities of a Novel Serine Bifunctional Protease Inhibitor from Adenanthera pavonina L. Seeds

, 2023
Rodrigo da Silva Gebara, Marciele Souza da Silva, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, Ana Eliza Zeraik, Elena Lassounskaia, Michelle Frazão Muzitano, Jorge Hudson Petretski, Valdirene Moreira Gomes, André de Oliveira Carvalho   +9 more
openalex   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Effect of Serine Protease Inhibitor on the Setting of Alaska Pollack Surimi Paste.

, 1996
Dajia Liu, Alam AKM Nowsad, Satoshi Kanoh, Eiji Niwa   +3 more
openalex   +2 more sources

Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro [PDF]

, 2004
Liangjun Lu, Edward Tam, Kent D. Stewart, John T. Randolph, Ron Pithawalla, Wenping He, Peggy Huang, Larry L. Klein, Hongmei Mo, Akhteruzzaman Molla   +9 more
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Production, purification and characterization of a thermostable alkaline serine protease from Bacillus lichniformis NMS-1 [PDF]

, 2015
Dilhani M.A.C, M S Gunathilaka R
openalex   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Molecular cloning of seprase: a serine integral membrane protease from human melanoma

, 1997
Leslie A. Goldstein, Giulio Ghersi, Mayra L. Piñeiro-Sánchez, Monica Salamone, Yunyun Yeh, Denise Flessate, Wen‐Tien Chen   +6 more
openalex   +1 more source