Results 211 to 220 of about 541,956 (367)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Targeting neutrophil serine proteases in bronchiectasis. [PDF]

Eur Respir J
Chalmers JD, Mall MA, Chotirmall SH, O'Donnell AE, Flume PA, Hasegawa N, Ringshausen FC, Watz H, Xu JF, Shteinberg M, McShane PJ.   +10 more
europepmc   +1 more source

Effects of the hydrogen bond between His 57 and Asp 102 on the lone pair molecular orbital of nitrogen of His 57 in serine proteases.

, 1980
Hideaki Umeyama, Setsuko Nakagawa
openalex   +2 more sources

Virulence in bacteriophage Mu: a case of trans-dominant proteolysis by the Escherichia coli Clp serine protease. [PDF]

, 1992
V. Geuskens, Amina Mhammedi-Alaoui, L. Desmet, Ariane Toussaint   +3 more
openalex   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis. [PDF]

BMC Mol Cell Biol
Kabir KMA, Takahashi T, Kikuchi T.
europepmc   +1 more source

Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. [PDF]

Cells, 2023
Ehret E, Stroh S, Auberson M, Ino F, Jäger Y, Maillard M, Szabo R, Bugge TH, Frateschi S, Hummler E.   +9 more
europepmc   +1 more source

Cutting Edge: IL-1β Processing during Pseudomonas aeruginosa Infection Is Mediated by Neutrophil Serine Proteases and Is Independent of NLRC4 and Caspase-1

Journal of Immunology, 2012
Mausita Karmakar, Yan Sun, A. Hise, A. Rietsch, E. Pearlman   +4 more
semanticscholar   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Identification and gene expression analysis of serine proteases and their homologs in the Asian corn borer Ostrinia furnacalis. [PDF]

Sci Rep, 2023
Yang L, Xu X, Wei W, Chen X, Peng C, Wang X, Xu J.   +6 more
europepmc   +1 more source