Results 241 to 250 of about 541,956 (367)

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

Animal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv, Ming Liu, Feifei Qi, Mingya Liu, Fengdi Li, Ran Deng, Xujian Liang, Yanfeng Xu, Zhiqi Song, Yiwei Yan, Shuyue Li, Guocui Mou, Linlin Bao   +12 more
wiley   +1 more source

Host Serine Proteases and Antiviral Innate Immunity as Potential Therapeutic Targets in Influenza A Virus Infection-Induced COPD Exacerbations. [PDF]

Int J Mol Sci
Bai H, Rodas M, Si L, Man Y, Ji J, Plebani R, Mercer JD, Powers RK, Belgur C, Jiang A, Hall SRR, Prantil-Baun R, Ingber DE.   +12 more
europepmc   +1 more source

Diarylethene-Based Photoswitchable Inhibitors of Serine Proteases. [PDF]

Angew Chem Int Ed Engl, 2021
Babii O, Afonin S, Diel C, Huhn M, Dommermuth J, Schober T, Koniev S, Hrebonkin A, Nesterov-Mueller A, Komarov IV, Ulrich AS.   +10 more
europepmc   +1 more source

Molecular and Biotechnological Aspects of Microbial Proteases

Microbiology and Molecular Biology Reviews, 1998
M. Rao, A. Tanksale, M. Ghatge, V. Deshpande   +3 more
semanticscholar   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases. [PDF]

Pharmaceuticals (Basel), 2022
Assylbekova A, Zhanapiya A, Grzywa R, Sienczyk M, Schönbach C, Burster T.   +5 more
europepmc   +1 more source

The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis.

, 1993
L. Appel, Mary Prout, Robin Abu-Shumays, Ann S. Hammonds, James C. Garbe, D Fristrom, James W. Fristrom   +6 more
openalex   +1 more source

Subtilases: The superfamily of subtilisin‐like serine proteases

Protein Science, 1997
R. Siezen, J. Leunissen
semanticscholar   +1 more source

Long-Range Electrostatics in Serine Proteases: Machine Learning-Driven Reaction Sampling Yields Insights for Enzyme Design. [PDF]

J Chem Inf Model
Zlobin A, Maslova V, Beliaeva J, Meiler J, Golovin A.   +4 more
europepmc   +1 more source

Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases. [PDF]

Front Chem, 2022
Ramos-Llorca A, Decraecker L, Cacheux VMY, Zeiburlina I, De Bruyn M, Battut L, Moreno-Cinos C, Ceradini D, Espinosa E, Dietrich G, Berg M, De Meester I, Van Der Veken P, Boeckxstaens G, Lambeir AM, Denadai-Souza A, Augustyns K.   +16 more
europepmc   +1 more source