Results 271 to 280 of about 541,956 (367)

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

, 2023
Corre M, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Structural Catalytic Core in Subtilisin-like Proteins and Its Comparison to Trypsin-like Serine Proteases and Alpha/Beta-Hydrolases. [PDF]

Int J Mol Sci
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source

The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.

, 1991
Marisa E. McGrath, Wade Hines, Judy A. Sakanari, R.J. Fletterick, Charles S. Craik   +4 more
openalex   +1 more source

Transcription of the Rat Serine Protease Inhibitor 2.1 Gene in Vivo: Correlation with GAGA Box Promoter Occupancy and Mechanism of Cytokine-Mediated Down-Regulation [PDF]

, 1998
Anne Emmanuelle Simar-Blanchet, Catherine Legraverend, J. Thissen, Alphonse Le Cam   +3 more
openalex   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

Homology-based identification and structural analysis of Pangasius hypophthalmus Annexins and Serine proteases to search molecules for wound healing applications. [PDF]

Comput Struct Biotechnol J
Avila Rodríguez MI, Velez Rueda AJ, Hernández-Pérez J, Benavides J, Sanchez ML.   +4 more
europepmc   +1 more source

Assignment<footref rid="foot01">¹</footref> of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25→q26 by in situ hybridization [PDF]

, 1999
Serguei Kozlov, Mariluce Riegel, Jochen Kinter, G. Hintsch, Paolo Cinelli, Albert Schinzel, P. Sonderegger   +6 more
openalex   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Neutrophil serine proteases in cystic fibrosis: role in disease pathogenesis and rationale as a therapeutic target. [PDF]

Eur Respir Rev
Mall MA, Davies JC, Donaldson SH, Jain R, Chalmers JD, Shteinberg M.   +5 more
europepmc   +1 more source