Results 341 to 350 of about 541,956 (367)
Some of the next articles are maybe not open access.
American Journal of Respiratory Cell and Molecular Biology, 2012
Uncontrolled proteolysis by neutrophil serine proteases (NSPs) in lung secretions is a hallmark of cystic fibrosis (CF). We have shown that the active neutrophil elastase, protease 3, and cathepsin G in CF sputum resist inhibition in part by exogenous ...
Alice V. Dubois +6 more
semanticscholar +1 more source
Uncontrolled proteolysis by neutrophil serine proteases (NSPs) in lung secretions is a hallmark of cystic fibrosis (CF). We have shown that the active neutrophil elastase, protease 3, and cathepsin G in CF sputum resist inhibition in part by exogenous ...
Alice V. Dubois +6 more
semanticscholar +1 more source
Serpins (Serine Protease Inhibitors)
Current Protocols in Protein Science, 2001AbstractSerpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's response to injury. This includes roles in coagulation, fibrinolysis, inflammation, wound healing, and tissue repair.
Susannah J. Bauman +2 more
openaire +3 more sources
AJP - Renal Physiology, 2012
Aldosterone plays an important role in the regulation of blood pressure by modulating the activity of the epithelial sodium channel (ENaC) that consists of α-, β-, and γ-subunits.
Kohei Uchimura +13 more
semanticscholar +1 more source
Aldosterone plays an important role in the regulation of blood pressure by modulating the activity of the epithelial sodium channel (ENaC) that consists of α-, β-, and γ-subunits.
Kohei Uchimura +13 more
semanticscholar +1 more source
The modular serine proteases of the complement cascade
Current Opinion in Structural Biology, 2012Modular serine proteases are central to the complement cascade of the mammalian humoral immune system. These proteases form protein complexes through multi-domain interactions to achieve their proteolytic activity. We review the structural insights into complement initiation by auto-activation of the hetero-tetrameric proteases of the large danger ...
FORNERIS, FEDERICO, Jin Wu, Piet Gros
openaire +5 more sources
Serine Proteases in Bone Disease
Current Rheumatology Reviews, 2009Serine proteases are active in many physiological and pathological processes within bone tissue. Although essential to adequate maintenance of bone and cartilage, their inappropriate expression can lead to exacerbation of tissue destruction and inflammation.
Bouteldja, N., Timson, D.J.
openaire +3 more sources
Microbial alkaline serine proteases: Production, properties and applications
World Journal of Microbiology & Biotechnology, 2021Fatema Matkawala +3 more
semanticscholar +1 more source
Coumarin and Isocoumarin as Serine Protease Inhibitors
Current Pharmaceutical Design, 2004Serine proteases are attractive targets for the design of enzyme inhibitors since they are involved in the etiology of several diseases. Within the class of serine proteases, HLE is one of the most destructive enzymes in the body. It is implicated in the promotion or exacerbation of a number of diseases including pancreatitis, acute respiratory ...
Bernard Masereel +2 more
openaire +3 more sources
Serine proteases: structure and mechanism of catalysis.
Annual Review of Biochemistry, 1977PERSPECTIVES AND SUMMARY .... 331 THE REACTION SEQUENCE AND INTERMEDIATES .... . .. . ..... 333 TRANSITION-STATE STABILIZATION .... .. . . . ... .. . 338 STRUCTURAL FEATURES PARTICIPATING IN CATALYSIS ........
J. Kraut
semanticscholar +1 more source
Cysteine and serine proteases in gastric cancer
Cancer, 1995Cysteine proteases (cathepsin B [CATB] and cathepsin L [CATL]), the serine protease urokinase-type plasminogen activator (UPA), and plasminogen activator inhibitor type-1 (PAI-1) are thought to play an important part in cancer invasion and metastasis.
PLEBANI, MARIO +10 more
openaire +4 more sources
Is histoaspartic protease a serine protease with a pepsin‐like fold?
Proteins: Structure, Function, and Bioinformatics, 2004AbstractThe primary structure of the so‐called histoaspartic protease from Plasmodium falciparum has a very high percentage of identity and homology with the pepsin‐like enzyme plasmepsin II. A homology modeling approach was used to calculate the three‐dimensional structure of the enzyme.
M. E. Popov +4 more
openaire +3 more sources