Results 11 to 20 of about 248,730 (279)
Natural serine proteases and their applications in combating amyloid formation [PDF]
ADMET and DMPKBackground and purpose: Amyloidosis is a group of diseases including diabetes type II and neurological disorders, such as Alzheimer’s disease, Parkinson’s disease, prion disease, etc., where a common trait is observed; accumulation of misfolded protein ...
Sanjay Metkar +3 more
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A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity [PDF]
MoleculesSerine proteases are a class of enzymes that orchestrate an immune response. These proteases can be hijacked by viruses to facilitate entry and spread, while simultaneously supporting the innate immune system in neutralizing pathogens.
Alua Shagirova +4 more
doaj +2 more sources
IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
Enrico di Cera
exaly +4 more sources
Extracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Streptococcus pneumoniae has evolved versatile strategies to colonize the nasopharynx of humans. Colonization is facilitated by direct interactions with host cell receptors or via binding to components of the extracellular matrix.
Murtadha Q. Ali +7 more
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Serine Proteases in Rodent Hippocampus [PDF]
Journal of Biological Chemistry, 1998 Brain serine proteases are implicated in developmental processes, synaptic plasticity, and in disorders including Alzheimer's disease. The spectrum of the major enzymes expressed in brain has not been established previously. We now present a systematic study of the serine proteases expressed in adult rat and mouse hippocampus.
Davies, Ben J. +4 more
core +8 more sources
Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases [PDF]
AMB ExpressStaphylococcus aureus is a Gram-positive opportunistic pathogen that has colonized nearly 30% of the human population and can cause life-threatening infections. S. aureus exports a variety of virulence factors, such as a novel set of extracellular serine
Felix L. Glinka +13 more
doaj +2 more sources
Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients [PDF]
Scientific Reports, 2023 Serine proteases are involved in many biological processes and are associated with irritable bowel syndrome (IBS) pathology. An increase in serine protease activity has been widely reported in IBS patients.
Souha Soussou +10 more
doaj +2 more sources
Serine proteases, their inhibitors and allergy [PDF]
Allergy: European Journal of Allergy and Clinical Immunology, 2006 This paper reviews four serine protease inhibitors and three protease gene defects that are associated with allergic conditions, suggesting an important role for these genes and their products in the development of allergy. Serine protease inhibitors may have a therapeutic potential in the treatment of allergy.
Smith, P K, Harper, J I
exaly +3 more sources
The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery [PDF]
BiomoleculesSerine proteases are multifunctional and versatile venom components found in viper snakes, including the Bothrops species, a widely distributed genus notorious for causing the highest number of snakebites across Latin America. These enzymes, representing
Marcela Romanazzi +12 more
doaj +2 more sources
Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview [PDF]
ToxinsToxicofera reptile venoms are composed of several toxins, including serine proteases. These proteases are glycosylated enzymes that affect the prey’s hemostatic system. Their actions extend across the coagulation cascade, the kallikrein–kinin system, and
Julia F. D. Vidal +7 more
doaj +2 more sources