Results 211 to 220 of about 249,259 (283)

Long-Range Electrostatics in Serine Proteases: Machine Learning-Driven Reaction Sampling Yields Insights for Enzyme Design. [PDF]

J Chem Inf Model
Zlobin A, Maslova V, Beliaeva J, Meiler J, Golovin A.   +4 more
europepmc   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

Angewandte Chemie, EarlyView.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda, Xingwang Deng, Edward Will, Thomas Emel, Maylin Romero, Christian Heinis   +5 more
wiley   +2 more sources

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration. [PDF]

Commun Biol
Corre MH, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source

A Comprehensive In Vitro Approach for Assessing the Physiological Degradation of Medical Implants: The Silkothane Arteriovenous Graft Case Study

Advanced NanoBiomed Research, EarlyView.
Evaluating the degradation of absorbable medical devices in vitro demands physiologically relevant conditions. This study presents a comprehensive framework applied to a three‐layered silk fibroin/polyurethane arteriovenous graft, employing human enzymes at physiological concentrations over 6 months. Multiparametric analyses of both graft structure and
Cristina Oldani, Alice Caldiroli, Federica Barzaghi, Nina Bono, Gabriele Candiani, Stefania Adele Riboldi   +5 more
wiley   +1 more source

In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores

Angewandte Chemie, EarlyView.
The generation of neoproteins—functional proteins containing unnatural amino acids—is a key goal in synthetic biology. We develop a platform to discover neoproteins with specified bioactivity from trillion‐member sequence libraries, using genetic code reprogramming, in vitro selection and microwave peptide synthesis.
Adam Beattie, Alexander Vinogradov, Chikako Okada, Toru Sengoku, Takayuki Katoh, Hiroaki Suga   +5 more
wiley   +2 more sources

Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. [PDF]

Autophagy
Yuan J, Ma J, Zhang F, Wang T, Jian X, Wang B, Li W, Zhang X, Cao Y, Yang H, Ma Y, Wang H.   +11 more
europepmc   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

New advances in understanding inhibition of myeloperoxidase and neutrophil serine proteases by two families of staphylococcal innate immune evasion proteins. [PDF]

Arch Biochem Biophys
Herdendorf TJ, Mishra N, Fatehi S, Gido CD, Prakash O, Geisbrecht BV.   +5 more
europepmc   +1 more source

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

, 2023
Corre M, Rey B, David SC, Torii S, Chiappe D, Kohn T.   +5 more
europepmc   +1 more source