Results 181 to 190 of about 128,354 (367)

Serine Proteinase Inhibitor 9 Can Be Recognized by Cytotoxic T Lymphocytes of Epithelial Cancer Patients [PDF]

, 2002
Koji Tanaka, Nanae Harashima, Fumihiko Niiya, Yoshiaki Miyagi, Naoya Hida, Mika Ochi, Nobue Imai, Mamoru Harada, Kyogo Itoh, Shigeki Shichijo   +9 more
openalex   +1 more source

Serine Proteinase Inhibitor Protein [PDF]

, 2020

openalex   +1 more source

STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches

Advanced Science, EarlyView.
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan, Dongxiao Cui, Jiajian Guo, Xiaojing Ma, Jiaming Wang, Linyue Guo, Tianyu Li, Mingrui Yang, Guangrui Huang, Anlong Xu, Wenfu Ma   +10 more
wiley   +1 more source

Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants

Bone Reports, 2020
Introduction: Although the number of patients undergoing total hip arthroplasty is constantly on the rise, we only have limited knowledge of the molecular mechanisms necessary for successful osseointegration of implants or the reasons why some fail ...
Jean Cassuto, Agnetha Folestad, Jan Göthlin, Henrik Malchau, Johan Kärrholm   +4 more
doaj  

Proteolytic enzyme systems [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Redl, H., Schlag, Günther   +4 more
core   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

New approaches to COPD

European Respiratory Review, 2005
No currently available treatments reduce the progression or suppress the inflammation of chronic obstructive pulmonary disease (COPD). However, with a better understanding of the inflammatory and destructive process, several targets have been identified,
P. J. Barnes
doaj  

Sequence‐ and Docking‐Site‐Dependent Contributions to Multi‐Site Phosphorylation of an Intrinsically Disordered MAPK Substrate

Advanced Science, EarlyView.
Real‐time NMR spectroscopy is used to study JNK1‐dependent phosphorylation of the intrinsically disordered substrate JIP1, revealing eleven phosphosites with distinct phosphorylation efficiencies. The site‐specific phosphorylation rates are shown to be determined by both the sequence position of the phosphosites relative to the two kinase docking site ...
Thibault Orand, Elise Delaforge, Marion Chenal, Maud Tengo, Torsten Herrmann, Juan Cortés, Pau Bernadó, Malene Ringkjøbing Jensen   +7 more
wiley   +1 more source

Pathobiochemistry of Sepsis [PDF]

, 1986
Duswald, Karl-Heimo, Fritz, Hans, Inthorn, D., Jochum, Marianne, Welter, H. F., Witte, J.   +5 more
core   +1 more source