Animal Models and Experimental Medicine, EarlyView.The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud +3 more
wiley +1 more source
Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source
It's a Trap!-Potential of Cathepsins in NET Formation. [PDF]
Int J Mol SciPruchniak P +6 more
europepmc +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation. [PDF]
Int J Mol SciZdybicka-Barabas A +3 more
europepmc +1 more source
Cathepsin B - indicator for the release of lysosomal cyasteine proteinases in severe trauma and inflammation [PDF]
, 1990 Assfalg-Machleidt, Irmgard +10 more
core +1 more source
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinaseCrystal structures of the serine-carboxyl proteinase from Pseudomonas sp. 101 (PSCP), complexed with a number of inhibitors, have been solved and refined at high- to atomic-level resolution. All of these inhibitors (tyrostatin, pseudo-tyrostatin, AcIPF, AcIAF, and chymostatin, as well as previously studied iodotyrostatin and pseudo-iodotyrostatin) make
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Complement and diverse enrichment of antibodies in intraluminal thrombi from abdominal aortic aneurysms may contribute to increased inflammation. [PDF]
Sci RepVidem V, Sharma A, Dahl T.
europepmc +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin +15 more
wiley +1 more source
Proteinase 3 is involved in presepsin production through neutrophil extracellular trap phagocytosis by macrophages. [PDF]
Sci RepIkegame A +6 more
europepmc +1 more source