Results 201 to 210 of about 128,354 (367)
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra+9 more
wiley +1 more source
P108 Stage specific expression of serine proteinase inhibitor in Trichinella spiralis
Isao Nagano+3 more
openalex +2 more sources
Post‐Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco
CK2αL phosphorylates TOE3 and enhances its stability, while FBXL1 promotes the ubiquitination‐degradation of TOE3 via the 26S proteasome. Compared to CK2αL‐phosphorylated TOE3, nonphosphorylated TOE3 shows a much higher affinity for FBXL1 and is more susceptible to ubiquitination‐degradation, thus facilitating viral infection. The regulatory mechanisms
Bolei Jiao+3 more
wiley +1 more source
Elastase-alpha1-proteinase inhibitor complex [PDF]
Bergmeyer, H. U.+4 more
core +1 more source
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan+12 more
wiley +1 more source
Inhibitors of Proteases: A Well-Grounded Strategy in Drug Development. [PDF]
Previti S, Ettari R.
europepmc +1 more source
Characterization of AWN‐1 glycosylated isoforms helps define the zona pellucida and serine proteinase inhibitor‐binding region on boar spermadhesins [PDF]
Juan J. Calvete+3 more
openalex +1 more source
AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei+13 more
wiley +1 more source
S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. [PDF]
Grek CL+6 more
europepmc +1 more source
Biochemistry and applications of Aprotimin, the kallikrein inhibitor from bovine organs. [PDF]
Fritz, Hans, Wunderer, G.
core +1 more source