Results 221 to 230 of about 37,649 (300)

Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas. [PDF]

ChemMedChem
Minneci M, Farkaš B, Rahman A, Kempf A, Nehlmeier I, Pöhlmann S, Rozas I.   +6 more
europepmc   +1 more source

The evolution of a genetic locus encoding small serine proteinase inhibitors. [PDF]

Biochem Biophys Res Commun, 2005
Clauss A, Lilja H, Lundwall A.
europepmc   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors. [PDF]

Toxins (Basel)
Lietz S, Barth H.
europepmc   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Proteinases and their inihibitors in septicemia [PDF]

, 1984
Neumann, S., Hörl, W. H., Jochum, Marianne, Fritz, Hans, Witte, J., Duswald, Karl-Heimo   +5 more
core  

It's a Trap!-Potential of Cathepsins in NET Formation. [PDF]

Int J Mol Sci
Pruchniak P, Niedzielska A, Nejfeld R, Wyżewski Z, Gregorczyk-Zboroch KP, Szulc-Dąbrowska L, Gieryńska M.   +6 more
europepmc   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation. [PDF]

Int J Mol Sci
Zdybicka-Barabas A, Stączek S, Kunat-Budzyńska M, Cytryńska M.   +3 more
europepmc   +1 more source

Serine proteinase and serine proteinase inhibitors of normal and degenerate knee joint menisci

, 1988
openaire   +1 more source