Results 211 to 220 of about 128,354 (367)

Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts

, 2003
Thangamani Muthukumar, Ruchuang Ding, Darshana M. Dadhania, Mara Medeiros-Domingo, Baogui Li, Vijay K. Sharma, Choli Hartono, David Serur, Surya V. Seshan, Hans‐Dieter Volk, Petra Reinke, Sandip Kapur, Manikkam Suthanthiran   +12 more
openalex   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Unveiling the structure, function and dynamics of StmPr1 in Stenotrophomonas maltophilia virulence. [PDF]

Sci Rep
Sommer M, Negm A, Outzen L, Windhorst S, Gabdulkhakov A, Weber W, Betzel C.   +6 more
europepmc   +1 more source

Processing of mitochondrial precursor proteins [PDF]

, 1991
Arretz, Michael, Neupert, Walter, Schneider, Helmut, Wienhues, Ulla   +3 more
core  

Proteinase-proteinase inhibitor imbalance in inflammation and multiple trauma with special amphasis on release of granulocytic lysosomal elastase [PDF]

, 1984
Dittmer, H., Duswald, Karl-Heimo, Elödi, P., Fritz, Hans, Jochum, Marianne   +4 more
core   +1 more source

NMR studies of internal dynamics of serine proteinase protein inhibitors: Binding region mobilities of intact and reactive‐site hydrolyzed Cucurbita maxima trypsin inhibitor (CMTI)‐III of the squash family and comparison with those of counterparts of CMTI‐V of the potato I family [PDF]

, 1998
Jianhua Liu, YuXi Gong, Om Prakash, Ramaswamy Krishnamoorthi, Lisa Wen, Insuk Lee, Jenq‐Kuen Huang   +6 more
openalex   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation. [PDF]

Int J Mol Sci
Zdybicka-Barabas A, Stączek S, Kunat-Budzyńska M, Cytryńska M.   +3 more
europepmc   +1 more source