Results 231 to 240 of about 128,354 (367)

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Importance of sputum and computed tomography assessments of airway neutrophil inflammation and mucus plugging in bronchiectasis management. [PDF]

ERJ Open Res
Tanabe N, Matsumoto H.
europepmc   +1 more source

Elafin Antiprotease Prevents the Development of Colitis in Mice by Inhibiting Two Neutrophil Serine Proteases: Elastase and Proteinase 3

, 2011
Jean‐Paul Motta, Julien Wartelle, Azzaq Belaaouaj, Delphyne Descamps, Michel Chignard, Jean-Michel Salllenave, Nathalie Vergnolle   +6 more
openalex   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source

Zebrafish sperm outsource activation to eggs' protease-activated receptors. [PDF]

PLoS Biol
Fissore RA, Lopes EM, Carpentiero F.
europepmc   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

To be, or not to be cleaved: Directed evolution of a canonical serine protease inhibitor against active and inactive protease pair identifies binding loop residue critical for prevention of proteolytic cleavage. [PDF]

Protein Sci
Köller Z, Németh BZ, Kiss B, Nagy ZA, Schlosser G, Magyar C, Demcsák A, Sahin-Tóth M, Pál G.   +8 more
europepmc   +1 more source

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

Comparative in vitro immunoreactivity and protein analysis of Trimeresurus albolabris and Tropidolaemus wagleri venoms. [PDF]

Sci Rep
Reamtong O, Pearngam P, Laoungbua P, Sitprija S, Thiangtrongjit T, Srisuk G, Vasaruchapong T, Khow O, Noiphrom J, Chaiyabutr N, Chanhome L, Kumkate S.   +11 more
europepmc   +1 more source

Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation. [PDF]

Nat Commun
Upadhyay T, Woods EC, Dela Ahator S, Julin K, Faucher FF, Uddin MJ, Hollander MJ, Pedowitz NJ, Abegg D, Hammond I, Eke IE, Wang S, Chen S, Bennett JM, Jo J, Lentz CS, Adibekian A, Fellner M, Bogyo M.   +18 more
europepmc   +1 more source