Results 81 to 90 of about 669,041 (311)

Der gespielte Ernst des Lebens: Bestandsaufnahme und Potenziale von Serious Games (for Health) [PDF]

, 2009
Serious Games werden aktuell im Zusammenhang mit den positiven Potenzialen von Computerspielen in verschiedenen Kontexten diskutiert. Im vorliegenden Beitrag werden die Entwicklung und der Forschungsstand des relativ neuen Konzeptes skizziert und ...
Lampert, Claudia, Schwinge, Christiane, Tolks, Daniel   +2 more
core   +2 more sources

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Editorial, Vol. 13, No. 1

International Journal of Serious Games
IJSG Editorial Vol.
Francesco Bellotti
doaj   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Serious games in mental health treatment: Review of literature [PDF]

, 2014
Serious games are considered as powerful tools in learning and instructional purposes. Besides, serious games also have gained-their own popularity among children and adolescents.
Mohd Rias, Riaza, Yusof, Norhana, Yusoff, Eizwan Hamdie   +2 more
core  

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

'I play, therefore I learn?' Measuring the Evolution of Perceived Learning and Game Experience in the Design Flow of a Serious Game [PDF]

, 2010
This article explores how the serious game Poverty Is Not a Game (PING) is experienced by high school students in its subsequent design stages. We first focus on the multifaceted construct of game experience and how it is related to serious games.
Courtois, Cédric, De Grove, Frederik, De Marez, Lieven, Van Looy, Jan   +3 more
core   +1 more source

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

Advanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
wiley   +1 more source

Editorial, Vol. 12, No. 1

International Journal of Serious Games
Editorial of IJSG Vol. 12, No. 1.
Francesco Bellotti
doaj   +1 more source

Assessing 3D Virtual World Disaster Training Through Adult Learning Theory

International Journal of Serious Games, 2014
As role-play, virtual reality, and simulated environments gain popularity through virtual worlds such as Second Life, the importance of identifying best practices for education and emergency management training becomes necessary.
Lee Taylor-Nelms, Valerie Hill
doaj   +1 more source