Results 251 to 260 of about 66,706 (287)

Serotonergic hypothesis of sleepwalking

Medical Hypotheses, 2005
Despite widespread prevalence of sleepwalking, its etiology and pathophysiology are not well understood. However, there is some evidence that sleepwalking can be precipitated by sleep-disordered breathing. A hypothesis is proposed that serotonergic system may be a link between sleep-disordered breathing and sleepwalking. Serotonergic neurons meet basic
Grzegorz R, Juszczak, Artur H, Swiergiel
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Serotonergic targets in depression

Current Opinion in Pharmacology, 2002
Serotonin reuptake inhibitors have proved to be a very effective treatment for depression and have strengthened the hypothesis that impaired 5-hydroxytryptamine (5-HT) neurotransmission may contribute to the underlying cause of depressive disorders. Extensive research has been carried out to investigate other 5-HT targets associated with the disease ...
Derek N, Middlemiss, Gary W, Price, Jeannette M, Watson   +2 more
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Serotonergic mechanisms in anxiety

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1994
1. Anatomical, behavioral, neurochemical and electrophysiological evidence collectively support a role for central 5-HT in the modulation of anxiety and the anti-anxiety action of the benzodiazepines. 2. The advent of selective agonists and antagonists for 5-HT receptor subtypes (5-HT1, 5-HT2, 5-HT3) has rekindled investigation of the role of 5-HT in ...
A S, Eison, M S, Eison
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Novel serotonergic and non-serotonergic migraine headache therapies

Expert Opinion on Therapeutic Patents, 2001
In the last four years discovery of pharmacotherapeutic treatments for migraine headaches has received much attention. Since the patent literature was last reviewed in 1997 [1], advances have been made in the understanding of mechanism and pathophysiology of migraine. Introduction of sumatriptan to the market has led to acceleration in research efforts
Abdelmalik Slassi, Methvin Isaac, Jalaj Arora   +2 more
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Serotonergic Genes and Suicidality

Crisis, 2001
Summary: Several lines of evidence indicate that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of depressive illness and suicidal behavior. Studies have shown that the number of brain and platelet serotonin transporter binding sites are reduced in patients with depression and in suicide victims ...
L, Du, G, Faludi, M, Palkovits, D, Bakish, P D, Hrdina   +4 more
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Serotonergic Functions in Man

2015
Abundant preclinical evidence suggests that serotonin-containing neural systems may participate in the regulation of both extrapyramidal and neuroendocrine function. In an attempt to examine these possibilities in man, patients with various neurologic disorders received drugs believed to facilitate or inhibit serotonergic function. Extrapyramidal signs
T N, Chase, I, Shoulson, A C, Carter
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Serotonergic mechanisms in hypertension

International Journal of Cardiology, 1993
Serotonin and abnormal serotonergic activity (both central and peripheral) may play a role in pathogenesis of essential hypertension. Serotonin acts chiefly via three types of receptors namely S1, S2 and S3 serotonergic receptors. Besides being vasoactive, it has some inotropic and chronotropic properties and also affects blood rheology.
M, Chandra, N, Chandra
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Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Neurogastroenterology & Motility, 2007
Abstract  Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity,
BUENO L., DE PONTI, FABRIZIO, FRIED M., KULLAK UBLICK G. A., KWIATEK M. A., POHL D., QUIGLEY E. M. M., TACK J., TALLEY N. J.   +8 more
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Serotonergic Mechanisms in Myoclonus

1979
Post-hypoxic intention myoclonus is a specific myoclonic syndrome in which central serotonergic tone may be deficient. Tryptophan and 5-hydroxytryptophan administration to patients with post-hypoxic intention myoclonus increases pre-existing low levels of 5-hydroxyindoleacetic acid levels in the cerebrospinal bluid, and also suppresses myoclonus ...
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PERIPHERAL SEROTONERGIC SYSTEM IN UREMIA

Thrombosis Research, 1996
Several data suggest that platelet-derived serotonin (5-HT), previously classified as a trivial modulator of blood-borne cardiovascular disease (1), may play a decisive role in various pathological processes, resulting from abnormal platelet-vessel wall interactions (2).
D, Pawlak, J, Malyszko, J S, Malyszko, K, Pawlak, W, Buczko, M, Mysliwiec   +5 more
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