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Irish Journal of Psychological Medicine, 2011
Serotonin toxicity is a potentially life-threatening condition associated with a range of psychotropic medications, co-administration of specific combinations of agents and overdose of certain drugs. It is associated with a wide diversity of clinical signs and symptoms, including cognitive, autonomic and somatic effects, as well as serious ...
Sobia, Nasim +3 more
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Serotonin toxicity is a potentially life-threatening condition associated with a range of psychotropic medications, co-administration of specific combinations of agents and overdose of certain drugs. It is associated with a wide diversity of clinical signs and symptoms, including cognitive, autonomic and somatic effects, as well as serious ...
Sobia, Nasim +3 more
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Science, 1973
The development of a radioimmunoassay for serotonin is described. Serotonin is made antigenic by coupling it to bovine serum albumin. Thrombocyte-free plasma instead of serum from the immunized animals is used for radioimmunoassay. Less than 1 ng serotonin can be measured by this procedure.
B, Peskar, S, Spector
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The development of a radioimmunoassay for serotonin is described. Serotonin is made antigenic by coupling it to bovine serum albumin. Thrombocyte-free plasma instead of serum from the immunized animals is used for radioimmunoassay. Less than 1 ng serotonin can be measured by this procedure.
B, Peskar, S, Spector
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Serotonin Transporter and Serotonin Receptors
2013The nature of the primary defect responsible for triggering and maintaining pulmonary artery smooth muscle (PA-SMC) proliferation in pulmonary artery hypertension (PAH) is poorly understood but may be either an inherent characteristic of PA-SMCs or a secondary response to an external abnormality, such as upregulation of growth factors.
Serge, Adnot +4 more
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Current Drug Target -CNS & Neurological Disorders, 2002
The serotonin transporter is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as antidepressants, but now are the most widely used agents in the treatment of many additional neuropsychiatric and related disorders.
Takeshi, Inoue +2 more
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The serotonin transporter is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as antidepressants, but now are the most widely used agents in the treatment of many additional neuropsychiatric and related disorders.
Takeshi, Inoue +2 more
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Australian and New Zealand Journal of Medicine, 1984
The realisation that serotonin plays a role not only in the carcinoid syndrome but also in migraine, nociception, dumping syndrome, vascular disease and hypertension, has led to an enormous amount of activity in search of serotonin antagonists. Numerous such pharmacological agents have been identified but only few have found their way into clinical use.
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The realisation that serotonin plays a role not only in the carcinoid syndrome but also in migraine, nociception, dumping syndrome, vascular disease and hypertension, has led to an enormous amount of activity in search of serotonin antagonists. Numerous such pharmacological agents have been identified but only few have found their way into clinical use.
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Neurology, 1995
We describe a patient treated with trazodone, isocarboxazid, and methylphenidate hydrochloride who developed confusion, agitation, poor concentration, rigidity, myoclonus, involuntary movements, orthostatic hypotension, and hyperreflexia. CK was normal, and the syndrome resolved spontaneously over 12 hours.
R A, Bodner, T, Lynch, L, Lewis, D, Kahn
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We describe a patient treated with trazodone, isocarboxazid, and methylphenidate hydrochloride who developed confusion, agitation, poor concentration, rigidity, myoclonus, involuntary movements, orthostatic hypotension, and hyperreflexia. CK was normal, and the syndrome resolved spontaneously over 12 hours.
R A, Bodner, T, Lynch, L, Lewis, D, Kahn
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Annals of Emergency Medicine, 1996
Selective serotonin reuptake inhibitors (SSRIs) are replacing tricyclic antidepressants (TCAs) with increasing frequency in the United States. Although SSRI poisoning tends to be less serious that TCA poisoning, the incidence of adverse side effects and drug interactions may be greater.
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Selective serotonin reuptake inhibitors (SSRIs) are replacing tricyclic antidepressants (TCAs) with increasing frequency in the United States. Although SSRI poisoning tends to be less serious that TCA poisoning, the incidence of adverse side effects and drug interactions may be greater.
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Serotonin Uptake and Serotonin Uptake Inhibition
Annals of the New York Academy of Sciences, 1990Serotonin uptake carriers occur on serotonin neurons, on glial cells and on blood platelets. The uptake carrier on serotonin neurons inactivates serotonin that has been released into the synaptic cleft by transporting it back into the nerve terminal. The serotonin uptake carrier is the means by which blood platelets acquire serotonin, since they do not
R W, Fuller, D T, Wong
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Journal of Neuroscience Nursing, 2006
Serotonin syndrome is a preventable, drug-related complication that results from increased brainstem serotonin activity, usually precipitated by the use of one or more serotonergic drugs. Its clinical presentation consists of autonomic dysfunction, alteration in mental status, and neuromuscular disorder.
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Serotonin syndrome is a preventable, drug-related complication that results from increased brainstem serotonin activity, usually precipitated by the use of one or more serotonergic drugs. Its clinical presentation consists of autonomic dysfunction, alteration in mental status, and neuromuscular disorder.
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Triptans, Serotonin Agonists, and Serotonin Syndrome (Serotonin Toxicity): A Review
Headache: The Journal of Head and Face Pain, 2010( Headache 2010;50:264‐272) The US Food and Drug Administration (FDA) have suggested that fatal serotonin syndrome (SS) is possible with selective serotonin reuptake inhibitors (SSRIs) and triptans: this warning affects millions of patients as these drugs ...
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