Results 51 to 60 of about 7,760 (160)
Pharmacology of novel psychoactive substances [PDF]
, 2016 This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
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Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.ABSTRACT Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non‐ordered process driven by chance and sharp observation.
Richard Head +2 more
wiley +1 more source
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Séquard syndrome [PDF]
, 2017 Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury.
Filli, Linard +3 more
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Serotoninergic and dopaminergic modulation of cortico-striatal circuit in executive and attention deficits induced by NMDA receptor hypofunction in the 5-choice serial reaction time task [PDF]
, 2014 Executive functions are an emerging propriety of neuronal processing in circuits encompassing frontal cortex and other cortical and subcortical brain regions such as basal ganglia and thalamus.
Mirjana Carli, Roberto W. Invernizzi
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Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.Serotonin receptors in areas of the emotion regulation network in human and rat brains a comparative autoradiographic study. Our systematic comparative analysis revealed significant differences of 5‐HT1A and 5‐HT2 receptor distributions and of their balance within and across components of the human emotion regulation network and homolog areas in rats ...
Anika Kuckertz +4 more
wiley +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. [PDF]
, 2019 Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential ...
Baraban, Scott C +5 more
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Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Role of serotonin in central dopamine dysfunction [PDF]
, 2010 The interaction between serotonin (5-HT) and dopamine (DA)-containing neurons in the brain is a research topic that has raised the interest of many scientists working in the field of neuroscience since the first demonstration of the presence of monoamine-
Di Giovanni, Giuseppe +2 more
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Pharmacological and neurophysiological aspects of space/motion sickness [PDF]
A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
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