Results 1 to 10 of about 71,732 (355)

Stereoselective Transaminase-Mediated Synthesis of Serotonin and Melatonin Receptor Agonists

Advanced Synthesis & Catalysis, 2022
AbstractTransaminase enzymes have significant potential for the stereoselective synthesis of drugs or drug precursors. Here, starting from one prochiral β‐tetralone, a short and efficient chemoenzymatic synthesis of four agonists of the serotonin/melatonin receptors have been developed.
Baud, Damien, Tappertzhofen, Nadine, Moody, Thomas S, Ward, John M, Hailes, Helen C   +4 more
openaire   +3 more sources

Examination of Migraine Management in Emergency Departments

Pain Research and Management, 2011
BACKGROUND: Despite advances in treatment, patients with migraine have been underdiagnosed and undertreated, specifically in emergency departments. In addition, great variability exists with respect to the diagnosis, management and treatment of migraine ...
Satnam S Nijjar, Leah Pink, Allan S Gordon   +2 more
doaj   +1 more source

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review

Frontiers in Psychiatry, 2020
Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition ...
Karen Van den Houte, Emidio Scarpellini, Wout Verbeure, Hideki Mori, Jolien Schol, Imke Masuy, Florencia Carbone, Jan Tack   +7 more
doaj   +1 more source

Current therapies in episodic migraine management [PDF]

Romanian Journal of Neurology, 2014
Migraine is a common neurological disease characterized by severe, recurrent episodes of throbbing, unilateral, headache. Non pharmacologic migraine treatment refers to the patient behavioural modification in order to avoid trigger.
Adina Roceanu, Ovidiu Bajenaru
doaj   +1 more source

The Influence of Hyperactivity of the Hypothalamic-pituitary-adrenal Axis and Hyperglycemia on the 5-HT2A Receptor-mediated Wet-dog Shake Responses in Rats [PDF]

, 2007
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induces hyperglycemia and serotonin (5-HT)2A receptor supersensitivity. In the present study, to investigate the effect of hyperglycemia on the function of 5-HT2A receptors, we compared the 5-
Amano, Manabu, Araki, Hiroaki, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Suemaru, Katsuya, Umeda, Yuichi, Yamaguchi, Takumi   +7 more
core   +1 more source

Advances in migraine treatment - a review

Quality in Sport
Introduction Migraine is a heavily debilitating disease  that ranks second place in Global Burden Disease. It is estimated that around 1 billion of people suffer from it.
Katarzyna Słychan, Agata Frańczuk, Aleksandra Makłowicz, Angelika Szpulak, Ewelina Kopczyńska, Julia Głoskowska, Michalina Grzelka, Katarzyna Kuleta, Aleksandra Elżbieta Łęska, Paulina Kejna   +9 more
doaj   +1 more source

Strain-dependent variations in stress coping behavior are mediated by a 5-HT/GABA interaction within the prefrontal corticolimbic system [PDF]

, 2015
Background: Serotonin and γ- Aminobutyric acid (GABA) transmission is crucial in coping strategies. Methods: Here, using mice from 2 inbred strains widely exploited in behavioral neurochemistry, we investigated whether serotonin transmission in medial ...
ANDOLINA, DIEGO, Maran, Dario, PUGLISI ALLEGRA, Stefano, Viscomi, Maria Teresa   +3 more
core   +1 more source

Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

Journal of Pharmacological Sciences, 2018
We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats.
Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo   +8 more
doaj   +1 more source

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation [PDF]

, 2016
FUNDING AND DISCLOSURE The research was funded by Wellcome Trust (WT098012) to LKH; and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM.
AH Rezvani, AJ Hill, B Doslikova, C Harvey-Lewis, C Miguelez, CD Wynne, Christopher M Bradshaw, CK Martin, CM Bradshaw, CM Olarte-Sanchez, CM Olarte-Sanchez, CM Olarte-Sanchez, Cristian M Olarte-Sánchez, David J Lyons, DD Lam, DJ Hayes, DJ Urban, ED Levin, G Bezzina, G Paxinos, GA Higgins, GM Alexander, GS Kranz, HY Meltzer, JC Halford, JD Salamone, JE Aberman, JE Blundell, L Valencia-Torres, LK Burke, LK Burke, LK Burke, LK Heisler, Lora K Heisler, Lourdes Valencia-Torres, M Filip, Martin G Myers, Megan Greenwald-Yarnell, MJ Bubar, MJ Bubar, NR Richardson, P Skjoldager, PJ Fletcher, PJ Fletcher, PR Killeen, PR Killeen, RJ DiLeone, S Burbassi, S Higgs, SM Graves, SP Vickers, Teodora Georgescu, V Di Matteo, W Hodos, WJ Thomsen, Y Xu   +55 more
core   +1 more source

Effects of Dopamine- and Serotonin-Related Compounds on Methamphetamine-Induced Self-Injurious Behavior in Mice

Journal of Pharmacological Sciences, 2004
Methamphetamine induces hyperlocomotion, and high doses of methamphetamine induce self-injurious behavior (SIB) in rodents. It is well known that the monoaminergic system is involved in methamphetamine-induced behavior.
Tomohisa Mori, Shinobu Ito, Taizo Kita, Toshiko Sawaguchi   +3 more
doaj   +1 more source