Results 11 to 20 of about 71,732 (355)
Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis [PDF]
Archives of Medical Science, 2018 Introduction Functional dyspepsia (FD) is typically treated with serotonin receptor (5-HT) agonists such as cisapride, mosapride, tegaserod and tandospirone citrate.
Man Jin +5 more
doaj +2 more sources
Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors [PDF]
, 2011 Subtype 2 serotonin (5-hydroxytryptamine, 5-HT) receptors are major drug targets for schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinogens, and gastrointestinal dysfunctions.' We report here ...
Abrol, Ravinder +4 more
core +4 more sources
Serotonin 2C receptor agonists and the behavioural satiety sequence in mice
Pharmacology Biochemistry and Behavior, 2002 The studies reported here examined the role of the 5-hydroxytryptamine (5-HT)(2C) receptor subtype in the control of ingestive behaviour in mice. Behavioural satiety sequence (BSS) and food intake measurements were taken, comparing the selective 5-HT(2C) receptor agonist (S)-2-(6-chloro-5-fluoro-indol-l-yl)-l-methylethylamine hydrochloride (Ro 60-0175;
Katherine N. Hewitt +3 more
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Triptans and CGRP blockade – impact on the cranial vasculature [PDF]
The Journal of Headache and Pain, 2017 The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP),
Silvia Benemei +9 more
doaj +5 more sources
Identification of serotonin 5-HT1A receptor partial agonists in ginger
Bioorganic & Medicinal Chemistry, 2010 Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the human serotonin 5-HT(1A) receptor with significant to moderate binding affinities (K(i)=3-20 microM).
Andreas Nievergelt +4 more
openalex +3 more sources
Cell Metabolism, 2007 The burden of type 2 diabetes and its associated premature morbidity and mortality is rapidly growing, and the need for novel efficacious treatments is pressing. We report here that serotonin 2C receptor (5-HT(2C)R) agonists, typically investigated for their anorectic properties, significantly improve glucose tolerance and reduce plasma insulin in ...
Zhou, Ligang +13 more
openaire +5 more sources
New opportunity for serotonin receptor agonists [PDF]
Nature Reviews Drug Discovery, 2008 openaire +3 more sources
Annals of Indian Academy of Neurology, 2022 Background: Migraine may be an important factor for paresthesia in the limbs, especially in the upper limbs. In several patients, paresthesia is responsible for a low quality of life.
Sayed Aliul Hasan Abdi +2 more
doaj +1 more source
Effect of Chronic Serotonin-2 Receptor Agonist or Antagonist Administration on Serotonin-1A Receptor Sensitivity [PDF]
Neuropsychopharmacology, 1998 We have investigated the effect of 5-HT2 receptor agonist or antagonist administration on postsynaptic 5-HT1A receptor sensitivity assessed by two behavioral measures, reciprocal forepaw treading or hypothermia induced by acute injection of the 5-HT1A receptor agonist 8-OH-DPAT.
J G, Hensler, K A, Truett
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Nature Communications, 2022 There are several models of how serotonergic psychedelic drugs affect brain activity. Here the authors use network control theory and functional MRI data to provide evidence that serotonin receptor agonists LSD and psilocybin flatten the brain’s dynamic ...
S. Parker Singleton +9 more
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