Results 11 to 20 of about 40,021 (309)

Serotonin 5-HT2C receptor homodimerization is not regulated by agonist or inverse agonist treatment [PDF]

European Journal of Pharmacology, 2007
Serotonin 5-HT(2C) receptors represent targets for therapeutics aimed at treating anxiety, depression, schizophrenia, and obesity. Previously, we demonstrated that 5-HT(2C) receptors function as homodimers. Herein, we investigated the effect of agonist and inverse agonist treatment on the homodimer status of two naturally occurring 5-HT(2C) receptor ...
Katharine, Herrick-Davis, Ellinor, Grinde, Barbara A, Weaver   +2 more
openaire   +2 more sources

Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols [PDF]

FEBS Letters, 1998
The serotonin type 1A (5‐HT1A) receptors are members of a superfamily of seven transmembrane domain receptors that couple to GTP binding regulatory proteins (G‐proteins). Serotonergic signalling has been shown to play an important role in alcohol tolerance and dependence.
Harikumar, K.G, Chattopadhyay, Amitabha
openaire   +2 more sources

Involvement of the Spinal Serotonergic System in the Analgesic Effect of [6]-Shogaol in Oxaliplatin-Induced Neuropathic Pain in Mice

Pharmaceuticals, 2023
Oxaliplatin is a chemotherapy drug that can induce severe acute neuropathy in patients within hours of treatment. In our previous study, 10 mg/kg [6]-shogaol (i.p.) significantly alleviated cold and mechanical allodynia induced by a 6 mg/kg oxaliplatin ...
Juan Gang, Keun-Tae Park, Suyong Kim, Woojin Kim   +3 more
doaj   +1 more source

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Cell Reports, 2017
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is ...
Yong Gao, Ting Yao, Zhuo Deng, Jong-Woo Sohn, Jia Sun, Yiru Huang, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hong Chen, Hongbo Guo, Jianqun Yan, Kathryn A. Cunningham, Yongsheng Chang, Tiemin Liu, Kevin W. Williams   +15 more
doaj   +1 more source

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. [PDF]

PLoS ONE, 2013
Multimodal analgesia is designed to optimize pain relief by coadministering drugs with distinct mechanisms of action or by combining multiple pharmacologies within a single molecule. In clinical settings, combinations of monoamine reuptake inhibitors and
Fei Shen, Pamela R Tsuruda, Jacqueline A M Smith, Glenmar P Obedencio, William J Martin   +4 more
doaj   +1 more source

A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent [PDF]

International Journal of Molecular Sciences, 2016
BW723C86, a serotonin receptor 2B agonist, has been investigated as a potential therapeutic for various conditions such as anxiety, hyperphagia and hypertension. However, the functional role of BW723C86 against melanogenesis remains unclear. In this study, we investigate the effect of serotonin receptor 2B (5-HTR2B) agonist on melanogenesis and ...
Eun Oh, Jong Park, Ji Lee, Cheol Myung, Su Kim, Sung Chang, Jae Hwang   +6 more
openaire   +3 more sources

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Buwalda, Bauke, Vegt, Bea J. van der,, van der Vegt, BJ, Ruiter, Anne J.H. de,, Jong, Jelly G. de,, Koolhaas, J.M., de Ruiter, Anne J.H., Bauke Buwalda, Sietse F de Boer, Koolhaas, Jaap M.,, van der Vegt, Bea J., de Jong, Jelly G., Koolhaas, JM, de Boer, SF, de Jong, JG, Buwalda, Bauke,, Buwalda, B, Bea J van der Vegt, Boer, Sietse F. de,, Anne J.H de Ruiter, Jelly G de Jong, de Boer, Sietse F., Jaap M Koolhaas, de Ruiter, AJH   +23 more
core   +1 more source

Serotonin mediation of early memory formation via 5HT2B receptor-induced glycogenolysis in the day-old chick

Frontiers in Pharmacology, 2014
Investigation of the effects of serotonin on memory formation in the chick revealed an action on at least two 5HT receptors. Serotonin injected intracerebrally produced a biphasic effect on memory consolidation with enhancement at low doses and ...
Marie Elizabeth Gibbs, Leif eHertz
doaj   +1 more source

Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation

iScience, 2020
Summary: The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying ...
Katsunori Kobayashi, Yasunori Mikahara, Yuka Murata, Daiki Morita, Sumire Matsuura, Eri Segi-Nishida, Hidenori Suzuki   +6 more
doaj   +1 more source

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source