Results 31 to 40 of about 40,021 (309)
Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]
, 2007 Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core +1 more source
Examination of Migraine Management in Emergency Departments
Pain Research and Management, 2011 BACKGROUND: Despite advances in treatment, patients with migraine have been underdiagnosed and undertreated, specifically in emergency departments. In addition, great variability exists with respect to the diagnosis, management and treatment of migraine ...
Satnam S Nijjar +2 more
doaj +1 more source
Serotonin 2C receptor agonists and the behavioural satiety sequence in mice
Pharmacology Biochemistry and Behavior, 2002 The studies reported here examined the role of the 5-hydroxytryptamine (5-HT)(2C) receptor subtype in the control of ingestive behaviour in mice. Behavioural satiety sequence (BSS) and food intake measurements were taken, comparing the selective 5-HT(2C) receptor agonist (S)-2-(6-chloro-5-fluoro-indol-l-yl)-l-methylethylamine hydrochloride (Ro 60-0175;
Hewitt, K +3 more
openaire +3 more sources
The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review
Frontiers in Psychiatry, 2020 Functional dyspepsia (FD) and gastroparesis (GP) are common disorders of the upper gastrointestinal tract. The pathophysiology of these conditions is likely to be heterogenous, and factors such as altered motility, sensitivity and response to nutrition ...
Karen Van den Houte +7 more
doaj +1 more source
Current therapies in episodic migraine management [PDF]
Romanian Journal of Neurology, 2014 Migraine is a common neurological disease characterized by severe, recurrent episodes of throbbing, unilateral, headache. Non pharmacologic migraine treatment refers to the patient behavioural modification in order to avoid trigger.
Adina Roceanu, Ovidiu Bajenaru
doaj +1 more source
Development of novel chiral capillary electrophoresis methods for the serotonin receptor (5-HT2A) antagonist MDL 100,907 (volinanserin) and for its key intermediate compound [PDF]
, 2014 Enantioselective capillary electrophoretic methods were elaborated for the determination of the enantiomeric purity of (R)-MDL 100,907 and its preparatively resolved key intermediate compound during the synthesis route. The pKa values of the intermediate
Palkó, Roberta +3 more
core +1 more source
Journal of Pharmacological Sciences, 2018 We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats.
Yuka Nakamura +8 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 Methamphetamine induces hyperlocomotion, and high doses of methamphetamine induce self-injurious behavior (SIB) in rodents. It is well known that the monoaminergic system is involved in methamphetamine-induced behavior.
Tomohisa Mori +3 more
doaj +1 more source
Endocytosis as a biological response in receptor pharmacology: evaluation by fluorescence microscopy. [PDF]
PLoS ONE, 2015 The activation of G-protein coupled receptors by agonist compounds results in diverse biological responses in cells, such as the endocytosis process consisting in the translocation of receptors from the plasma membrane to the cytoplasm within ...
Víctor M Campa +6 more
doaj +1 more source
, 2014 Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Farideh A. Javid +5 more
core +1 more source