Results 51 to 60 of about 40,021 (309)

The role of GABAB(1) receptor isoforms in anxiety and depression : genetic and pharmacological studies in the mouse [PDF]

, 2007
Anxiety and depression disorders represent common, serious and growing health problems world-wide. The neurobiological basis of anxiety and depression, however, remains poorly understood.
Jacobson, Laura Helen
core   +1 more source

Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges

Angewandte Chemie International Edition, EarlyView.
Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley   +1 more source

Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease

Parkinson's Disease, 2012
L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease.
Eunju Shin, Elisabetta Tronci, Manolo Carta   +2 more
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

A computational pipeline for a neurotransmitter-centric analysis of the effects of psychiatric medication on EEG spectral power

Frontiers in Psychiatry
IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation.
Samar Samy Zekerallah, Anna Alexandra Maxion, Anna Alexandra Maxion, Jana Zweerings, Paula Teucher, Paula Teucher, Klaus Mathiak, Ekaterina Kutafina, Arnim Johannes Gaebler, Arnim Johannes Gaebler   +9 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Effects of Serotonergic Agonists and Antagonists on the Competitive Behaviour of Rats [PDF]

Records of Pharmaceutical & Biomedical Sciences
SWhen  animals  are  housed  in  a  group,  they  form  social  hierarchy,  which  may have a great influence on the cognitive abilities and health of the individuals of this group. The rank order of this social hierarchy may have its consequences on the
Mirna ElAwady, Reem Hazem, Manal Abdelhady, Dina Khodeer   +3 more
doaj   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Serotonin receptor modulators in the treatment of irritable bowel syndrome

Therapeutics and Clinical Risk Management, 2008
Mohammad Fayyaz, Jeffrey M LacknerDivision of Gastroenterology, Department of Medicine, University at Buffalo School of Medicine, SUNY, Buffalo, NY, USAAbstract: The aim of this article is to review the pathophysiology and clinical role of serotonin ...
Mohammad Fayyaz, Jeffrey M Lackner
doaj