Results 121 to 130 of about 25,888 (267)

Efficacy and Safety of Pregabalin and Alpha‐Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open‐Label, Non‐Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess the efficacy and safety of alpha‐lipoic acid (ALA) and pregabalin, both as mono and combination therapy, for treating painful diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus, with the hypothesis that pregabalin monotherapy is non‐inferior to combination therapy.
Tae Jung Oh, Sang Soo Kim, Seung‐Hwan Lee, Hyuk‐Sang Kwon, Eun Sook Kim, Eun‐Jung Rhee, Hye Jin Yoo, Han Na Jang, Woo Je Lee, Eun Sook Kim, Sang Yong Kim, Gwanpyo Koh, Eun‐Gyoung Hong, Tae Sun Park, Jong Chul Won   +14 more
wiley   +1 more source

Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner

Journal of Pharmacological Sciences, 2017
Serotonin/noradrenaline reuptake inhibitors (SNRIs) are widely used for the treatment for major depressive disorder, but these drugs induce several side effects including increased aggression and impulsivity, which are risk factors for substance abuse ...
Iku Tsutsui-Kimura, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshioka   +3 more
doaj   +1 more source

Pharmacological Interaction With the Sigma1 (σ1)-Receptor in the Acute Behavioral Effects of Antidepressants

Journal of Pharmacological Sciences, 2011
Selective agonists of the sigma-1 (σ1) ligand–operated chaperone protein, like igmesine or PRE-084, are antidepressants in preclinical depression models.
Vanessa Villard, Johann Meunier, Nathalie Chevallier, Tangui Maurice   +3 more
doaj   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, EarlyView.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Escitalopram for the management of major depressive disorder: a review of its efficacy, safety, and patient acceptability

Patient Preference and Adherence, 2012
Eiji Kirino1,21Department of Psychiatry, Juntendo University Shizuoka Hospital, Shizuoka, Japan; 2Department of Psychiatry, Juntendo University School of Medicine, Tokyo, JapanAbstract: Escitalopram (escitalopram oxalate; Cipralex®, Lexapro& ...
Kirino E
doaj  

Psychogenic polydipsia in dogs – a review of pathogenesis, diagnosis and treatment

Journal of Small Animal Practice, EarlyView.
Polyuria and polydipsia represent a common clinical presentation in dogs and may result from numerous disorders affecting different body systems. Compulsive water consumption is characteristic of psychogenic polydipsia, a primary polydipsia disorder rooted in neurologic, behavioural or environmental factors.
G. Pavlovsky
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed‐breed dogs, weighing 15.33 ± 2.25 kg, participated in a two‐treatment crossover design: G1 received intravenous dipyrone (25 ...
Andressa Nunes Mouta, Kathryn Nóbrega Arcoverde, Robson dos Anjos Honorato, Naftáli Silva Fernandes, Caio Vinicius Almeida de Oliveira, Glícia Cavalcante Mesquita, Yanna Deysi Bandeira Passos, Gabriel Araújo‐Silva, Valéria Veras de Paula   +8 more
wiley   +1 more source

Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Major depressive disorder (MDD) is widely considered to be a mood disorder characterized by altered connectivity. The thalamus plays an important role in MDD by connecting large areas of the brain. Here, we explored thalamic connectivity in MDD at the subnuclear level using ultra‐high‐field MRI.
Weijian Liu, Shu Liu, Jurjen Heij, Laurens A. van de Mortel, Luka Liebrand, Matthan Caan, Wietske van der Zwaag, Dick J. Veltman, Lin Lu, Moji Aghajani, Guido van Wingen   +10 more
wiley   +1 more source

Evaluation of the analgesic effect of venlafaxine, a serotonin and noradrenaline reuptake inhibitor

, 2015
Objectives: The aim of this study was to test the analgesic effects of the antidepressant venlafaxine in several experimental models of nociception. Conclusions: These results corroborate researche that reported the inhibitory effect of venlafaxine on the signs of spontaneous pain and hindpaw mechanical and thermal hypersensitivity in ...
Magalhaes, Rosane, Jamille Felix, Albuquerque, Juliana, Bastos, Maria Vilani, Glauce Viana, Fonteles, Marta, Felix, Francisco, Juvenia Fontenele   +7 more
openaire   +1 more source