Results 71 to 80 of about 1,525,501 (301)

Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris, Irmgard Tegeder, Tegeder Irmgard, Laura Popp, Wijnvoord, Nina, Myrczek, Thekla, Tegeder, Irmgard, Wijnvoord Nina, Popp, Laura, Annett Häussler, Häussler, Annett, Nina Wijnvoord, Myrczek Thekla, Häussler Annett, Popp Laura, Boris Albuquerque, Albuquerque, Boris, Thekla Myrczek   +17 more
core   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Neurotransmitter receptor gene expression patterns associated with reward-related neural representations

Neuroscience Research
The neural representation of reward is underpinned by neurotransmitter systems; however, current human neuroimaging techniques cannot assess the receptor-specific contributions to reward processing.
Kaosu Matsumori, Kana Matsuyanagi, Kenji Matsumoto   +2 more
doaj   +1 more source

Serotonin antagonism improves platelet inhibition in clopidogrel low-responders after coronary stent placement: an in vitro pilot study. [PDF]

PLoS ONE, 2012
Increased residual platelet reactivity remains a burden for coronary artery disease (CAD) patients who received a coronary stent and do not respond sufficiently to treatment with acetylsalicylic acid and clopidogrel.
Daniel Duerschmied, Ingo Ahrens, Maximilian Mauler, Christoph Brandt, Stefanie Weidner, Christoph Bode, Martin Moser   +6 more
doaj   +1 more source

Serotonin Function During Embryonic Development: The 5-HT2B Receptor Contribution

, 2021
During embryogenesis some neurotransmitters, including serotonin, function as morphogens before being coopted in the central nervous system. Serotonin uptake sites first appear in non-neural tissues such as the heart, the liver, the cranial mesenchyme ...
Nardi I., Irma Nardi, Michela Ori, Ori M.   +3 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

An exploration of the serotonin system in antisocial boys with high levels of callous-unemotional traits. [PDF]

PLoS ONE, 2013
The serotonin system is thought to play a role in the aetiology of antisocial and aggressive behaviour in both adults and children however previous findings have been inconsistent.
Caroline Moul, Carol Dobson-Stone, John Brennan, David Hawes, Mark Dadds   +4 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.

PLoS ONE, 2013
Neuromodulation, the alteration of individual neuron response properties, has dramatic consequences for neural network function and is a phenomenon observed across all brain regions and taxa.
Andrew M Dacks, Vincenzina Reale, Yeli Pi, Wujie Zhang, Joel B Dacks, Alan J Nighorn, Peter D Evans   +6 more
doaj   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source