Results 81 to 90 of about 1,423,567 (298)

Serotonin, serotonin receptors and their actions in insects

Neurotransmitter, 2015
Serotonin is an ancient monoamine neurotransmitter, biochemically derived from tryptophan. It is most abundant in the gastrointestinal tract, but is also present throughout the rest of the body of animals and can even be found in plants and fungi. Serotonin is especially famous for its contributions to feelings of well-being and happiness.
Vleugels, Rut, Verlinden, Heleen, Vanden Broeck, Jozef   +2 more
openaire   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Cell Reports, 2017
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is ...
Yong Gao, Ting Yao, Zhuo Deng, Jong-Woo Sohn, Jia Sun, Yiru Huang, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hong Chen, Hongbo Guo, Jianqun Yan, Kathryn A. Cunningham, Yongsheng Chang, Tiemin Liu, Kevin W. Williams   +15 more
doaj   +1 more source

Antagonista do receptor da serotonina reverte a hipotensão e a hiporeatividade vascular no choque endotoxêmico em ratos [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2015.O choque séptico é caracterizado principalmente por vasodilatação excessiva, hipotensão e ...
Metzker, Kiuanne Lino Lobo
core  

The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle, Silvia Iñiguez‐Barrio, Maria Aurora Arrue, Leire Erkoreka   +3 more
wiley   +1 more source

The Effects of Serotonin in Immune Cells

Frontiers in Cardiovascular Medicine, 2017
Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body’s serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation.
Nadine Herr, Christoph Bode, Daniel Duerschmied   +2 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: Sleep deprivation (SD) leads to the disturbance of the estrous cycle. Serotonin, the levels of which increase with SD, has been shown to inhibit luteinizing hormone production and the receptor has been found in the follicles.
Chueh-Ko Yang, Rick Sai-Chuen Wu, Cheng-Hsuan Wu, Theodore Rong-Yei Lin, Horng-Der Tsai   +4 more
doaj   +1 more source

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system

Nature Communications
The nervous system flexibly processes information under different conditions. To do this, neural networks frequently rely on uniform expression of modulatory receptors by distinct classes of neurons to fine tune the computations supported by each ...
Julius Jonaitis, Mohd F. E. B. Mazri, John W. Hageter, Oliver Cook, Tyler R. Sizemore, Marryn M. Bennett, Jacob D. Ralston, Farzaan Salman, Emma J. Fletcher, Danielle E. Matheny, Johnston Renton, Keshav L. Ramachandra, Eric J. Horstick, Andrew M. Dacks   +13 more
doaj   +1 more source