Results 161 to 170 of about 71,732 (355)

Serotonin receptor agonists in the acute treatment of migraine: a review on their therapeutic potential. [PDF]

J Pain Res, 2018
Negro A, Koverech A, Martelletti P.
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Agonist high and low affinity state ratios predict drug intrinsic activity and a revised Ternary complex mechanism at serotonin 5-HT2A and 5-HT2C receptors

, 2000
Christina Egan, Ellinor Grinde, Ann DuPre, Bryan Roth, Michael Hake, Milt Teitler, Katharine Herrick-Davis   +6 more
openalex   +1 more source

Serotonin 2A Receptor Agonist Binding in the Human Brain with [¹¹C]Cimbi-36 [PDF]

, 2014
Anders Ettrup, Sophie da Cunha-Bang, Brenda McMahon, Szabolcs Lehel, Agnete Dyssegaard, Anine W Skibsted, Louise Møller Jørgensen, Martin Hansen, Anders Ohlhues Baandrup, Søren Bache, Claus Svarer, Jesper L. Kristensen, Nie Gillings, Jacob Madsen, Gitte M. Knudsen   +14 more
openalex   +1 more source

An Improved, Scalable Synthesis of the Selective Serotonin 2A Receptor Agonist 25CN-NBOH [PDF]

, 2021
Jesper L. Kristensen, Emil Märcher-Rørsted, Jitka Nykodemová   +2 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

The structural diversity of psychedelic drug actions revealed

Nature Communications
There is currently a resurgence in exploring the utility of classical psychedelics to treat depression, addiction, anxiety disorders, cluster headaches, and many other neuropsychiatric disorders. A biological target of these compounds, and a hypothesized
Ryan H. Gumpper, Manish K. Jain, Kuglae Kim, Renhong Sun, Ning Sun, Zhongli Xu, Jeffrey F. DiBerto, Brian E. Krumm, Nicholas J. Kapolka, H. Ümit Kaniskan, David E. Nichols, Jian Jin, Jonathan F. Fay, Bryan L. Roth   +13 more
doaj   +1 more source

Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist

, 2004
Kimberly E. Vanover, Scott C. Harvey, Thomas Son, Stefania Risso Bradley, Henriette Kold, Malath Makhay, Isaac Veinbergs, Tracy A. Spalding, David M. Weiner, Carl Magnus Andersson, Bo‐Ragnar Tolf, Mark R. Brann, Uli Hacksell, Robert E. Davis   +13 more
openalex   +1 more source

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Induced by Selective Agonist of Serotonin 5-HT1 Receptor – A Case Report [PDF]

, 2022
Barbara Maini de Carvalho, Matheus Alves Da Silva, André Luiz, Hennan Salzedas Teixeira, Marcelo Freitas Schimid, Karlla Danielle Ferreira Lima, Christiane Monteiro de Siqueira Campos, Ione Feijão Alexim, Alex Machado Baêta   +8 more
openalex   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source