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Biased Signaling in Psychedelic Action. [PDF]

Annu Rev Pharmacol Toxicol
Wacker D, McCorvy JD.
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Oral Serotonin Receptor Agonists

PharmacoEconomics, 2005
Migraine headache is a highly prevalent chronic, episodic condition. The direct and indirect costs of migraine headache have a tremendous economic impact in the US. Research has shown that serotonin (5HT(1B/D)) receptor agonists reduce healthcare costs, improve health-related QOL (HR-QOL), decrease migraine disability and keep patients effective in the
Jennifer H, Lofland, David B, Nash
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Clinical pharmacology of the serotonin receptor agonist, zolmitriptan

Expert Opinion on Drug Metabolism & Toxicology, 2007
Migraine is a common, often disabling, neurovascular disease that has been shown to be associated with abnormal serotonergic activity. Drugs that modulate serotonin receptors are commonly used in the acute treatment of a migraine attack. Zolmitriptan, a 5-hydroxytryptophan(1B/1D) receptor agonist, is once such drug that is used in acute migraine ...
B Lee, Peterlin, Alan M, Rapoport
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Antidepressant-like behavioral effects of serotonin receptor agonists

Neuroscience & Biobehavioral Reviews, 1994
The clinical discoveries that drugs that stimulate 5-HT neurotransmission, either by inhibiting 5-HT uptake or by stimulating postsynaptic receptors directly, have antidepressant properties has stimulated interest in defining the role of the 5-HT receptor system in the clinical effects of antidepressant drugs.
I, Lucki, A, Singh, D S, Kreiss
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Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia

NeuroReport, 2009
Dopamine replacement therapy for the treatment of Parkinson's disease leads to deleterious abnormal involuntary movements (AIMs), known as L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia, which parallels enhanced striatal dopamine D1 receptor-mediated signaling. Recent evidence suggests stimulation of striatal serotonin (5-HT) 1B receptors may
Karen L Eskow, Jaunarajs, Kristin B, Dupre, Aimee, Steiniger, Anna, Klioueva, Alexander, Moore, Catherine, Kelly, Christopher, Bishop   +6 more
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Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist

The Journal of Pediatrics, 1997
Apneusis is a disturbance of respiratory rhythm characterized by severely prolonged inspiratory effort. It may occur after damage to the respiratory network within the lower brain stem and pons from an overdose of central nervous system depressants, blockade of glutamate receptors, asphyxia, hypoxia, or ischemia.
B, Wilken, P, Lalley, A M, Bischoff, H J, Christen, J, Behnke, F, Hanefeld, D W, Richter   +6 more
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Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord

General Pharmacology: The Vascular System, 1991
1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT), the 5-HT1B ...
T, Crisp, J L, Stafinsky, L J, Spanos, M, Uram, V C, Perni, H B, Donepudi   +5 more
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