Results 291 to 300 of about 71,732 (355)

Predicting Long‐Term Depression Progression in Parkinson's Disease: A Machine‐Learning Survival Analysis and Risk Score

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
We developed and internally validated a machine learning–based survival model for predicting long‐term progression of dPD. Supported by SHAP analysis, the model identified that depressive symptom severity, cognitive impairment, and autonomic dysfunction were the main key clinical predictors for dPD progression.
Defu Liu, Chong Qi, Jiansong Huang, Hutao Xie, Yutong Zhuang, Quan Zhang, Xuemin Zhao, Tianqi Hu, Guofan Qin, Yue Lu, Xin Zhang, Sizhe Li, Mingyu Yang, Jianguo Zhang, Yin Jiang   +14 more
wiley   +1 more source

GTP release-selective agonists prolong opioid analgesic efficacy. [PDF]

Nature
Stahl EL, Swanson MA, Dang VQ, Cameron MD, Kennedy NM, Bannister TD, Bohn LM.   +6 more
europepmc   +1 more source

Evolution of Drug Development Trends in Multiple Sclerosis: Analysis of Mainland China and Global Landscapes From 2004 to 2024

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
This registry‐based analysis of 1183 MS clinical trials (2004–2024) shows sustained global activity and a marked increase in mainland China after 2018, predominantly driven by late‐phase and bioequivalence studies. Trial density varied across regions, and IFNAR, CD20, and S1PR1 were the most frequently investigated targets. ABSTRACT Background Multiple
Chaoyang Chen, Zhenyu Niu, Ting Yang, Xuanling Zhang, Ran Wei, Xiaocong Pang, Ran Liu, Ying Zhou   +7 more
wiley   +1 more source

Evaluating the association between migraine treatments and tinnitus: Insights from the US Food and Drug Administration adverse event reporting system. [PDF]

PLoS One
Kim Y, Yook Y, Rhee SJ.
europepmc   +1 more source

Evaluation of the activity of functionally selective 5-$HT_{1a}$ serotonin receptor agonists in rat behavioral models

Wilczyńska, Daria
openalex   +1 more source

Vitamin D as a Regulator of the Biological Clock-Implications for Circadian-Metabolic Dysregulation. [PDF]

Int J Mol Sci
Vesković M, Šutulović N, Djuric E, Hrnčić D, Marković AR, Stanojlović O, Mladenović D.   +6 more
europepmc   +1 more source

Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT_1A Receptor for Therapeutic Potential in Depression and Anxiety. [PDF]

Research (Wash D C)
Li SJ, Yuan QN, Wu WY, Chen ZH, Chen D, Shan H, Chu QY, Hu W, Wu K, Liu T, Zhu YY, Hou L, Zhou J, Duan J, Duan JA, Xu HE, Ma HY.   +16 more
europepmc   +1 more source

Weight Regain After GLP-1-Based Therapy Discontinuation: Failure, Physiology, or Follow-Up Gap. [PDF]

Cureus
Quimbayo-Cifuentes AF.
europepmc   +1 more source

Adrenergic signaling during parasitic infections. [PDF]

Front Immunol
Gardias P, Bąska P.
europepmc   +1 more source