Results 271 to 280 of about 40,021 (309)
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Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists
Journal of Computer-Aided Molecular Design, 2004The N-terminal extracellular regions of heterooligomeric 3AB-type human 5-hydroxytryptamine receptors (5-HT3ABR) were modelled based on the crystal structure of snail acetylcholine binding protein AChBP. Stepwise rotation of subunit A by 5 degrees was performed between -10 degrees and 15 degrees to mimic agonist binding and receptor activation ...
Gábor Maksay +2 more
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Serotonin (5-HT)1A Receptor Agonists and Neuroprotection
1993The activation of serotonin (5-HT)1Areceptors exerts an inhibitory influence on neuronal activity in a way similar to the activation of adenosine Al receptors. Adenosine Al receptor agonists have been shown to exert neuroprotective effects in animal models of cerebral ischemia.
J. Traber, K. M. Bode-Greuel, E. Horvath
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Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist
Acta Physiologica Scandinavica, 2000There is mounting evidence that increased brain serotonin during exercise is associated with the onset of CNS‐mediated fatigue. Serotonin receptor sensitivity is likely to be an important determinant of this fatigue. Alterations in brain serotonin receptor sensitivity were examined in Wistar rats throughout 6 weeks of endurance training, running on a ...
D, Dwyer, J, Browning
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1993
Gaddum and Picarelli (1957) initially suggested the existence of more than one serotonin (5-HT) receptor over 30 years ago. Subsequently, neurophysiological, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems ...
K P, Lesch, C S, Aulakh, D L, Murphy
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Gaddum and Picarelli (1957) initially suggested the existence of more than one serotonin (5-HT) receptor over 30 years ago. Subsequently, neurophysiological, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems ...
K P, Lesch, C S, Aulakh, D L, Murphy
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Current Topics in Medicinal Chemistry, 2007
This review deals with the literature (1982-2006) concerning bivalent ligands for dopamine (D) and serotonin (5-HT) receptors, as well as for their respective transporters. The design, synthesis, and pharmacological evaluation of bivalent agonists and antagonists for dopamine and serotonin receptors have been successfully pursued.
Michael, Decker, Jochen, Lehmann
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This review deals with the literature (1982-2006) concerning bivalent ligands for dopamine (D) and serotonin (5-HT) receptors, as well as for their respective transporters. The design, synthesis, and pharmacological evaluation of bivalent agonists and antagonists for dopamine and serotonin receptors have been successfully pursued.
Michael, Decker, Jochen, Lehmann
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Effect of Selective Serotonin Receptor Agonists on Prolactin Secretion in Male Rats
Neuroendocrinology, 2008The effect of different serotonin (5-HT) receptor agonists on the release of prolactin (PRL) was investigated in conscious male rats. The 5-HT<sub>1</sub> receptor agonists 5-carboxamidotryptamine and RU 24969 stimulated the PRL secretion dose dependently.
Jørgensen, H., Knigge, U., Warberg, J.
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Migraine headache treatment with eletriptan, a second-generation serotonin receptor agonist
Drugs of Today, 2001Eletriptan is a member of the triptan family of selective serotonin receptor agonists. These act against migraine by inducing vasoconstriction of the meningeal arteries. In pharmacological tests, eletriptan has shown high affinity for the 5-HT(1B/1D) receptors, which have been implicated in the etiology of migraine headache attacks.
P., Cole, X., Rabasseda
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Journal of the Autonomic Nervous System, 1995
Spontaneous neuronal activity in the solitary tract nucleus was recorded extracellularly in a brain slice preparation during bath-application of 5-HT1 and 5-HT2 receptor-selective agonists and antagonists. The 5-HT1A/5-HT1B agonist 5-carboxamidotryptamine depressed activity in 20 of 25 neurons studied. The remaining five neurons were unaffected.
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Spontaneous neuronal activity in the solitary tract nucleus was recorded extracellularly in a brain slice preparation during bath-application of 5-HT1 and 5-HT2 receptor-selective agonists and antagonists. The 5-HT1A/5-HT1B agonist 5-carboxamidotryptamine depressed activity in 20 of 25 neurons studied. The remaining five neurons were unaffected.
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[Serotonin 5- HT4 receptor agonist (mosapride citrate)].
Nihon rinsho. Japanese journal of clinical medicine, 2006Irritable bowel syndrome is a functional gastrointestinal disorder characterized by abnormal sensation and motility in the lower gastrointestinal tract. In constipation-type irritable bowel syndrome, decreased bowel motility causes stagnation of feces and gas, resulting in enhanced pain sensation of the bowel. Mosapride citrate is a selective serotonin
Takeo, Odaka +4 more
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Serotonin receptor ontogeny: Effects of agonists in 1-day-old rats
Pharmacology Biochemistry and Behavior, 1992Although numerous subtypes of serotonin [5-hydroxytryptamine (5-HT)] receptors have been identified in the newborn rat by radioligand binding studies, there have been few studies of the functional significance of these early receptors, most without the benefit of selective drugs.
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