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Identification of serotonin 5-HT1A receptor partial agonists in ginger
Bioorganic & Medicinal Chemistry, 2010 Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the human serotonin 5-HT(1A) receptor with significant to moderate binding affinities (K(i)=3-20 microM).
Nievergelt, Andreas +4 more
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Investigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
ACS Chemical Neuroscience, 2020The 2,5-dimethoxyphenethylamine (2,5-PEA) scaffold is recognized as a motif conferring potent agonist activity at the serotonin 2A receptor (5-HT2AR). The 2,5-dimethoxy motif is present in several classical phenethylamine psychedelics such as 2,4,5- trimethoxyamphetamine (TMA-2), 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-iodoamphetamine (
Emil Marcher-Rørsted +2 more
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Receptor-Based 3D QSAR Analysis of Serotonin 5-HT1D Receptor Agonists
Collection of Czechoslovak Chemical Communications, 2005 A three-dimensional quantitative structure-activity relationship study (3D QSAR) has been successfully applied to explain the binding affinities for the serotonin 5-HT1Dreceptor of a triptan series. The paper describes the development of a receptor-based 3D QSAR model of some known agonists and recently developed triptans on the 5-HT1Dserotonergic ...
Nalan Terzioglu, Hans-Dieter Höltje
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Oral Serotonin Receptor Agonists
PharmacoEconomics, 2005Migraine headache is a highly prevalent chronic, episodic condition. The direct and indirect costs of migraine headache have a tremendous economic impact in the US. Research has shown that serotonin (5HT(1B/D)) receptor agonists reduce healthcare costs, improve health-related QOL (HR-QOL), decrease migraine disability and keep patients effective in the
Jennifer H, Lofland, David B, Nash
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Clinical pharmacology of the serotonin receptor agonist, zolmitriptan
Expert Opinion on Drug Metabolism & Toxicology, 2007Migraine is a common, often disabling, neurovascular disease that has been shown to be associated with abnormal serotonergic activity. Drugs that modulate serotonin receptors are commonly used in the acute treatment of a migraine attack. Zolmitriptan, a 5-hydroxytryptophan(1B/1D) receptor agonist, is once such drug that is used in acute migraine ...
B Lee, Peterlin, Alan M, Rapoport
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Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist
The Journal of Pediatrics, 1997Apneusis is a disturbance of respiratory rhythm characterized by severely prolonged inspiratory effort. It may occur after damage to the respiratory network within the lower brain stem and pons from an overdose of central nervous system depressants, blockade of glutamate receptors, asphyxia, hypoxia, or ischemia.
B, Wilken +6 more
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Antidepressant-like behavioral effects of serotonin receptor agonists
Neuroscience & Biobehavioral Reviews, 1994The clinical discoveries that drugs that stimulate 5-HT neurotransmission, either by inhibiting 5-HT uptake or by stimulating postsynaptic receptors directly, have antidepressant properties has stimulated interest in defining the role of the 5-HT receptor system in the clinical effects of antidepressant drugs.
I, Lucki, A, Singh, D S, Kreiss
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