Results 151 to 160 of about 196,073 (309)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation. [PDF]

J Enzyme Inhib Med Chem, 2023
Stępnicki P, Wronikowska-Denysiuk O, Zięba A, Targowska-Duda KM, Bartyzel A, Wróbel MZ, Wróbel TM, Szałaj K, Chodkowski A, Mirecka K, Budzyńska B, Fornal E, Turło J, Castro M, Kaczor AA.   +14 more
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, EarlyView.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Ergotamine Stimulates Human 5-HT₄-Serotonin Receptors and Human H₂-Histamine Receptors in the Heart. [PDF]

Int J Mol Sci, 2023
Jacob H, Braekow P, Schwarz R, Höhm C, Kirchhefer U, Hofmann B, Neumann J, Gergs U.   +7 more
europepmc   +1 more source

An Investigation of Key Symptoms That Account for the Early Response Effect During Psychological Therapy for Eating Disorders

European Eating Disorders Review, EarlyView.
ABSTRACT Objective The early response effect, defined as a reliable symptomatic improvement during the initial phase of treatment, is the most robust predictor of recovery following eating disorder treatment. This study aimed to investigate which symptom domains mostly influence the early response effect. Methods Data from N = 232 adult patients (90.8%
Ammara Imtiaz, Caroline Bell, Glenn Waller, Jaime Delgadillo   +3 more
wiley   +1 more source

Serotonin Receptors as Therapeutic Targets for Autism Spectrum Disorder Treatment. [PDF]

Int J Mol Sci, 2022
Lee A, Choo H, Jeon B.
europepmc   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source