Results 111 to 120 of about 86,902 (236)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

The importance of serotonin in the gastrointestinal tract

Journal of Education, Health and Sport, 2017
Introduction. Serotonin also called as 5-hydroxytryptamine (5-HT) is a very important neurotransmitter in the central nervous system, also plays an important role in the gastrointestinal tract.
Jarosław Koza, Renata Kwiatkowska, Adam Jurgoński, Małgorzata Pujanek, Monika Ameryk, Piotr Sikorski, Agnieszka Meder, Maciej Świątkowski   +7 more
doaj  

The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID

Immunology &Cell Biology, EarlyView.
In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe, Lauren A Jones, Alyce M Martin, Rosemary A Coleman, Caitlin Allman, Rochelle A Peterson, Damien J Keating   +6 more
wiley   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Serotonin syndrome induced by Bromfed DM in a patient on sertraline. [PDF]

SAGE Open Med Case Rep
Jung JK, Zazay I, Burmeister JR, Shaghaghi N.   +3 more
europepmc   +1 more source

Endoscopic Ultrasound for the Management of Pancreatic Neuroendocrine Tumors: Diagnosis, Treatment, and Future Perspectives

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Pancreatic neuroendocrine tumors (PanNETs) are increasingly diagnosed, reflecting greater clinical awareness, improved imaging, and revised classification. This review summarizes evidence on epidemiology, diagnostic workup, and endoscopic ultrasound (EUS)–guided management of PanNETs, encompassing diagnostic evaluation, tissue acquisition, and
Angelo Bruni, David Meacci, Roberto Falbo, Marco Fichera, Francesco Poggioli, Riccardo Casadei, Claudio Ricci, Leonardo Henry Eusebi   +7 more
wiley   +1 more source

Sertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report. [PDF]

BMC Psychiatry
Liu L, Zhang ZR, Chen CF.
europepmc   +1 more source

Dental Implants in Adults With Intellectual Disabilities: A Multicenter Retrospective Study. Part 1: Implant Outcomes

Journal of Oral Rehabilitation, EarlyView.
This multicenter retrospective study evaluated implant survival and peri‐implant health in adults with non‐syndromic intellectual disability. Among 453 implants with long‐term follow‐up, survival exceeded 92%, with tissue‐level implants and cement‐retained restorations associated with healthier peri‐implant conditions. These findings support the use of
Márcio Diniz‐Freitas, Manuel Bratos‐Bobo, Manuel Bratos‐Morillo, Denise Faulks, Marie‐Sophie Bogner, Melanie Derchu, Caroline Eschevins, Emmanuel Nicolas, Pierre Yves Cousson, Chantal Auduc, Yoo Soo‐Yeon, Pedro Diz‐Dios, Pablo Gasamáns‐García, Jacobo Limeres‐Posse, Paolo Appendino, Simone Buttiglieri, Francesco Della Ferrera, Roberto Rozza, Fabio Brusamolino, Javier Fernández‐Feijoo   +19 more
wiley   +1 more source

Cocaine-Induced Rhabdomyolysis With Acute Kidney Injury in the Absence of Serotonin Syndrome: A Case Report. [PDF]

Cureus
Adiat M, Nafees S, Kumar V, Abdelfattah M, Javeed A, Anwar MM, Zamari K, Riasat MH, Chohan MT.   +8 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source