Results 151 to 160 of about 4,051,537 (300)
Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
Serotonin syndrome is a potentially life-threatening drug-induced condition. It is characteristically described as combination of recent ingestion of a drug likely to alter post-synaptic serotonin levels and a clinical triad of: 1. Mental status changes
Hennessy, Arthur, Lynch, Jessie
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Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Mohamad Abi Nassif +4 more
wiley +1 more source
COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model
Movement Disorders, EarlyView.Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin +10 more
wiley +1 more source
Apathy in Lewy Body Disorders: A Position Paper
Movement Disorders, EarlyView.Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Serotonin Syndrome after Concomitant Treatment with Linezolid and Citalopram [PDF]
, 2017 Linezolid, a new synthetic antimicrobial, is an important weapon against methicillin-resistant Staphylococcus aureus (MRSA). Although there are reports of serotonin syndrome developing after concomitant use of linezolid and the selective serotonin ...
Stern, R. +3 more
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Emergencies in Amyotrophic Lateral Sclerosis
Muscle &Nerve, EarlyView.ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal +9 more
wiley +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background Despite often coexisting, the association between mental disorders and malnutrition is not well characterized. This study aimed to describe the prevalence of mental disorders and their association with malnutrition, nutritional interventions, and clinical outcomes.
Vivian V. Nguyen +5 more
wiley +1 more source
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source