Results 1 to 10 of about 53,447 (349)

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

Journal of Pharmacological Sciences, 2013
Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression.
Md. Shenuarin Bhuiyan, Hideaki Tagashira, Kohji Fukunaga   +2 more
doaj   +3 more sources

Flunarizine as a potential repurposed drug for the serotonin transporter inhibition: an integrated approach for therapeutic development against major depressive disorder [PDF]

Frontiers in Pharmacology
Major depressive disorder (MDD) is a serious neuropsychiatric condition that affects millions of people worldwide, causing significant psychological distress and lifestyle deterioration.
Abdelbaset Mohamed Elasbali, Abdelbaset Mohamed Elasbali, Ahmed S. Ali, Ahmed S. Ali, Taj Mohammad, Mohd Adnan, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan   +8 more
doaj   +2 more sources

Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas [PDF]

British Journal of Cancer, 1982
Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism.
P. J. M. Tutton, David H. Barkla
openalex   +5 more sources

Synthesis of a selective serotonin uptake inhibitor: [11C]citalopram

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1990
Citalopram, a selective serotonin uptake inhibitor, was labeled with 11C for non-invasive in vivo studies of serotonin uptake sites in the human brain using positron emission tomography. The synthesis was completed in approximately 17 min using [11C]methyl iodide as the precursor.
R. F. Dannals, Hayden T. Ravert, Alan A. Wilson, H.N. Wagner   +3 more
openalex   +4 more sources

Selective serotonin re-uptake inhibitors: use in depression [PDF]

Psychiatric Bulletin, 1992
This short review outlines the clinical profile of the selective serotonin re-uptake inhibitors (SSRIs). There has been much recent publicity and promotion of this group of drugs and this review attempts to give a balanced account of their current place in the treatment of depression. Although a large number of preclinical and clinical trials have been
I. Nicol Ferrier, Trevor Silverstone, D. Eccleston   +2 more
openalex   +3 more sources

Selective serotonin re-uptake inhibitors affect craniofacial structures in a mouse model.

PLoS ONE
Selective serotonin re-uptake inhibitors (SSRI) widely used in the treatment of depression, anxiety, obsessive compulsive disorder, fibromyalgia, and migraine are among the most heavily prescribed drug class in the United States (US).
Quinn N Saluan, George R Bauer, Heema Vyas, Amr Mohi, Emily L Durham, James J Cray   +5 more
doaj   +2 more sources

Drug-Resistant Hyponatremia after Escitalopram Intake: A Series of Two Case Reports [PDF]

Annals of Geriatric Medicine and Research, 2021
The consumption of new selective serotonin reuptake inhibitors (SSRIs) is raising dramatically especially in European countries. It contributes to occurrence of clinically important drug side effects. One of which can be hyponatremia. We present two case
Justyna Kacperczyk, Adrian Perdyan, Małgorzata Stompór   +2 more
doaj   +1 more source

Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives

Pharmaceutics, 2021
Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) and selective serotonin and noradrenaline reuptake inhibitors (SNRIs).
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud   +6 more
doaj   +1 more source

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Journal of Experimental & Clinical Cancer Research, 2021
Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations

Neurology International, 2021
Serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit the presynaptic neuronal uptake of serotonin and norepinephrine and prolong the effects of the monoamines in the synaptic cleft within the central nervous system, leading to increased ...
David Fanelli, Gregory Weller, Henry Liu
doaj   +1 more source