Results 1 to 10 of about 25,164 (313)

Crucial Interactions Between Selective Serotonin Uptake Inhibitors and Sigma-1 Receptor in Heart Failure

Journal of Pharmacological Sciences, 2013
Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression.
Md. Shenuarin Bhuiyan, Hideaki Tagashira, Kohji Fukunaga   +2 more
doaj   +3 more sources

Drug-Resistant Hyponatremia after Escitalopram Intake: A Series of Two Case Reports [PDF]

Annals of Geriatric Medicine and Research, 2021
The consumption of new selective serotonin reuptake inhibitors (SSRIs) is raising dramatically especially in European countries. It contributes to occurrence of clinically important drug side effects. One of which can be hyponatremia. We present two case
Justyna Kacperczyk, Adrian Perdyan, Małgorzata Stompór   +2 more
doaj   +1 more source

Effect of Selected Antidepressants on Placental Homeostasis of Serotonin: Maternal and Fetal Perspectives

Pharmaceutics, 2021
Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) and selective serotonin and noradrenaline reuptake inhibitors (SNRIs).
Hana Horackova, Rona Karahoda, Lukas Cerveny, Veronika Vachalova, Ronja Ebner, Cilia Abad, Frantisek Staud   +6 more
doaj   +1 more source

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Journal of Experimental & Clinical Cancer Research, 2021
Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations

Neurology International, 2021
Serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit the presynaptic neuronal uptake of serotonin and norepinephrine and prolong the effects of the monoamines in the synaptic cleft within the central nervous system, leading to increased ...
David Fanelli, Gregory Weller, Henry Liu
doaj   +1 more source

Faster Serotonin Clearance in CA3 Region of Hippocampus and Antidepressant-like Effect of Decynium-22 in Juvenile Mice Are Putatively Linked to Increased Plasma Membrane Monoamine Transporter Function: Implications for Efficacy of Antidepressants in Juveniles

Cells, 2022
Selective serotonin reuptake inhibitors (SSRIs) are less efficacious in treating depression in children than in adults. SSRIs block serotonin uptake via the high-affinity, low-capacity serotonin transporter.
Melodi A. Bowman, Jorge A. Gomez, Nathan C. Mitchell, Anne M. Wells, Melissa Vitela, Kyra M. Clarke, Rebecca E. Horton, Wouter Koek, Lynette C. Daws   +8 more
doaj   +1 more source

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes

EJNMMI Research, 2021
Background The therapeutic use of [131I]meta-iodobenzylguanidine ([131I]MIBG) is often accompanied by hematological toxicity, primarily consisting of severe and persistent thrombocytopenia.
Thomas Blom, Rutger Meinsma, Franca di Summa, Emile van den Akker, André B. P. van Kuilenburg, Marten Hansen, Godelieve A. M. Tytgat   +6 more
doaj   +1 more source

Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety

Frontiers in Cellular Neuroscience, 2022
Depression and anxiety are common, debilitating psychiatric conditions affecting millions of people throughout the world. Current treatments revolve around selective serotonin reuptake inhibitors (SSRIs), yet these drugs are only moderately effective at ...
Nikita Deo, Gregory Redpath
doaj   +1 more source

The C-Terminal Region of Serotonin Transporter Is Important for Its Trafficking and Glycosylation

Journal of Pharmacological Sciences, 2009
We investigated the effects of brefeldin A and ilimaquinone, inhibitors of membrane trafficking, using serotonin transporter (SERT)–expressing COS-7 cells.
Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Sakai   +8 more
doaj   +1 more source

Bleeding risk between newer direct-acting oral anticoagulants and selective serotonin reuptake inhibitors. Case report and literature review

European Psychiatry, 2021
Introduction The use of selectiveserotonin reuptake inhibitors (SSRIs) is an independent risk factor for bleeding events. Antidepressants and oral anticoagulants (OACs) are often prescribed together as depression and anxiety often coexist with ...
T. Gutiérrez Higueras, F. Calera Cortés, S. Sainz De La Cuesta Alonso, S. Vicent Forés   +3 more
doaj   +1 more source