Results 91 to 100 of about 219,974 (370)

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

A relationship between dengue virus serotype and the clinical severity in paediatric patients from Gondokusuman region, Yogyakarta between 1995 and 1999

Pediatria i Medycyna Rodzinna, 2016
Aim of the study: Dengue infection occurs almost all over subtropical and tropical countries. Dengue pathogenesis explaining its clinical manifestations is still unclear. Indonesia is a country with several hyperendemic regions.
Sri Poeranto, Sutaryo Sutaryo, Hari Kusnanto Josef, Mohammad Juffrie   +3 more
doaj   +1 more source

One year period of invasive pneumococcal disease in children from a tertiary care hospital in Turkey in the post-vaccine era

Human Vaccines & Immunotherapeutics, 2021
The incidence of invasive pneumococcal disease (IPD) has decreased after pneumococcal conjugate vaccine used; however, a breakthrough infection may still be seen after vaccination.
Gulnihan Ustundag, Eda Karadag-Oncel, Sebahat Sen-Tas, Ahu Kara-Aksay, Dilek Yilmaz-Ciftdogan, Nisel Yilmaz, Mehmet Ceyhan   +6 more
doaj   +1 more source

Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing

Antibiotics, 2023
Salmonella is the leading cause of death associated with foodborne illnesses in the USA. Difficulty in treating human salmonellosis is attributed to the development of antimicrobial resistance and the pathogenicity of Salmonella strains. Therefore, it is
Menuka Bhandari, Jelmer W. Poelstra, Michael Kauffman, Binta Varghese, Yosra A. Helmy, Joy Scaria, Gireesh Rajashekara   +6 more
doaj   +1 more source

GeoDEN: A Visual Exploration Tool for Analysing the Geographic Spread of Dengue Serotypes [PDF]

Computer Graphics Forum (2025)
Static maps and animations remain popular in spatial epidemiology of dengue, limiting the analytical depth and scope of visualisations. Over half of the global population live in dengue endemic regions. Understanding the spatiotemporal dynamics of the four closely related dengue serotypes, and their immunological interactions, remains a challenge at a ...
arxiv   +1 more source

Pneumococcal serotype evolution in Western Europe

BMC Infectious Diseases, 2015
BackgroundPneumococcal diseases remain a leading cause of vaccine-preventable death worldwide in children
M. Tin Tin Htar, D. Christopoulou, H. Schmitt   +2 more
semanticscholar   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Prevalence and Molecular and Antimicrobial Characteristics of Cronobacter spp. Isolated From Raw Vegetables in China

Frontiers in Microbiology, 2018
Cronobacter spp. is a foodborne pathogen that causes life-threatening and invasive diseases, such as necrotizing enterocolitis, meningitis, and sepsis.
Na Ling, Na Ling, Chengsi Li, Jumei Zhang, Qingping Wu, Haiyan Zeng, Wenjing He, Yingwang Ye, Juan Wang, Yu Ding, Moutong Chen, Liang Xue, Qinghua Ye, Weipeng Guo   +13 more
doaj   +1 more source

Invasive Pneumococcal Disease in Adults in Portugal: The Importance of Serotypes 8 and 3 (2015–2018)

Microorganisms, 2021
Increasing the uptake of the 13-valent pneumococcal conjugate vaccine (PCV13) in children is expected to alter the serotypes causing invasive pneumococcal disease (IPD) in adults due to herd protection.
Catarina Silva-Costa, Joana Gomes-Silva, Inês Teodoro, Mário Ramirez, José Melo-Cristino, on behalf of the Portuguese Group for the Study of Streptococcal Infections   +5 more
doaj   +1 more source

Selective and Genetic Constraints on Pneumococcal Serotype Switching

PLoS Genetics, 2015
Streptococcus pneumoniae isolates typically express one of over 90 immunologically distinguishable polysaccharide capsules (serotypes), which can be classified into "serogroups" based on cross-reactivity with certain antibodies.
N. Croucher, L. Kagedan, C. Thompson, J. Parkhill, S. Bentley, J. Finkelstein, M. Lipsitch, W. Hanage   +7 more
semanticscholar   +1 more source