Results 61 to 70 of about 234,349 (284)

Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011. [PDF]

, 2014
BackgroundSince the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years.
Bennett, Nancy, Blain, Amy, Briere, Elizabeth, Clark, Thomas, Cohn, Amanda, Farley, Monica M, Harrison, Lee H, Lexau, Catherine, MacNeil, Jessica, Miller, Lisa, Nichols, Megin, Petit, Susan, Reingold, Arthur, Schaffner, William, Thomas, Ann, Wang, Xin   +15 more
core   +1 more source

Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]

, 2020
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
core   +2 more sources

Fourth Human Parechovirus Serotype [PDF]

Emerging Infectious Diseases, 2006
We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
Marcel Beld, Manon E Luken, Katja C. Wolthers, Janke Schinkel, Hetty van Eijk, Christina M. J. E. Vandenbroucke-Grauls, Peter J M van den Broek, Matthias F. C. Beersma, Negassi Menelik, Kimberley S. M. Benschop, Hans L. Zaaijer   +10 more
openaire   +3 more sources

Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration

Advanced Science, EarlyView.
There are multiple therapeutic agents available for the treatment of both dry age‐related macular degeneration (AMD) and wet AMD. It is essential to continue innovation by introducing new drug delivery technologies that can incorporate those along with patient compliance and the accessibility of the technology into the early stages of research and ...
J Jesus Rodriguez‐Cruz, Jessica Cutrufello, Michael Lam, Shreya Nallaparaju, Nicholas A. Peppas   +4 more
wiley   +1 more source

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile [PDF]

, 2013
<p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both ...
AA Soyombo, AC Bradshaw, AC Bradshaw, AF Merrick, AH Baker, AL Parker, AL Parker, Alan L Parker, Andrew H Baker, Angela C Bradshaw, Audrey F Wright, B Vigl, C-C Liang, Christian Delles, DM Roberts, F Sakurai, F Vigant, K Doronin, Katie M White, KD Newman, M Hedman, M Hedman, M Jessup, MC Sprangers, MD Rekhter, MJE Havenga, MM Zanone, MO Hilutnen, N Inoue, O Kalyuzhniy, P Lemarchand, R Alba, R Alba, R Vogels, Raul Alba, RD Lopes, Robert A McDonald, RR Bradley, S Ishii, S Kuriyama, SA Nicklin, SD Carson, SJ George, SJ George, SM Sumida, SN Waddington, TD Henry, TW Johnson   +47 more
core   +2 more sources

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. [PDF]

, 1985
The variable major proteins (VMP) of serotypes 7 and 21 of the relapsing fever agent Borrelia hermsii were isolated by detergent extraction and high performance liquid chromatography.
Barbour, AG, Barstad, PA, Coligan, JE, Raum, MG   +3 more
core  

Capsular profiling of the Cronobacter genus and the association of specific Cronobacter sakazakii and C. malonaticus capsule types with neonatal meningitis and necrotizing enterocolitis [PDF]

, 2015
Background: Cronobacter sakazakii and C. malonaticus can cause serious diseases especially in infants where they are associated with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis.
A Lehner, A Muller, A Rahman, AS Shashkov, C Iversen, C Iversen, C Whitfield, DL Daniels, E Hurrell, E Hurrell, E Jackson, E Kucerova, E Kucerova, EE Jackson, F Ramos-Morales, GI Dancer, H Kim, H Sonbol, J Caubilla-Barron, J Caubilla-Barron, J Kajimura, JR Mehall, K Butela, KA Jolley, KA Power, KG Jarvis, KG Jarvis, LL MacLean, LL MacLean, LM Willis, LS Harris, M Blažková, M Czerwicka, M Hobbs, M Scheepe-Leberkühne, MW Gilmour, N Mullane, N Navasa, NP Arbatsky, O Holy, O Holy, P. Ogrodzki, PN Danese, S Hariri, S Joseph, S Joseph, S Joseph, S Joseph, S Joseph, S Kumar, S. Forsythe, SJ Forsythe, SM Townsend, SM Townsend, T Carver, X Zogaj, Y Sun, Y Sun   +57 more
core   +2 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

Angewandte Chemie, EarlyView.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink‐Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +2 more sources